Not even the priciest threads can match the wonders of a simple spider web: Dragline silk is stronger than Kevlar and stretchier than nylon. For more than 100 years, that’s had entrepreneurs and scientists scheming of ways to mass produce it. Now, a researchers have spliced dragline silk genes into mammalian cells and showed for the first time that harvested proteins can be spun into strong, lightweight fibers.Researchers have struggled to splice spider silk genes into other organisms in hopes of recovering enough silk to produce bolts of high-strength material. And although they’ve inserted the genes into bacteria, yeast, and plants, the result has always been disappointing. Even when the proteins have been extracted and purified, they yield only worthless, brittle fibers.A team led by researchers at Nexia Biotechnologies near Montreal, Canada, thought it might have more luck by transferring silk genes into certain mammalian cells that, like those in the spider, secrete silk-building proteins in a water-based solution. Led by molecular biologists Anthoula Lazaris and Costas Karatzas, the team spliced the silk genes into two different cell lines: bovine mammary cells, which excel at secreting proteins outside the cell; and hamster kidney cells, which produce large volumes of recombinant proteins. Both cell lines secreted soluble silk proteins outside the cells, where they could easily be collected.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Then came the big test: Could the proteins be spun into fibers? To find out, the Nexia researchers teamed up with fiber-spinning experts at the U.S. Army Soldier Biological Chemical Command in Natick, Massachusetts. When one of the proteins, dubbed MaSpI, was extracted from water and injected into a methanol solution, the proteins formed strong fibers, the group reports in the 18 January issue of Science (p. 472). Although this new fiber is less flexible than spider fibers, Karatzas thinks that may be because his team’s fibers are made from only one of the two proteins spiders use to spin theirs.The progress “is highly encouraging,” says Randy Lewis, a molecular biologist and spider silk expert at the University of Wyoming in Laramie. Lewis says that if the process of harvesting silk from cell cultures is perfected, it will lead to ultrastrong, flexible fibers for everything from artificial tendons and ligaments to lightweight body armor and high-strength composites.Related sitesNexia research and developmentU.S. Army Soldier Biological Chemical CommandArachnology and spider webs
The World Health Organization (WHO) mostly works to reduce the physical toll of disease. But last week it turned to another kind of harm: the insult and stigma inflicted by diseases named for people, places, and animals. Among the existing monikers that its new guidelines “for the Naming of New Human Infectious Diseases” would discourage: Ebola, swine flu, Rift Valley Fever, Creutzfeldt-Jakob disease, and monkey pox. Instead, WHO says researchers, health officials, and journalists should use more neutral, generic terms, such as severe respiratory disease or novel neurologic syndrome.Many scientists agree that disease names can be problematic, but they aren’t sure the new rulebook is necessarily an improvement. “It will certainly lead to boring names and a lot of confusion,” predicts Linfa Wang, an expert on emerging infectious diseases at the Australian Animal Health Laboratory in Geelong. “You should not take political correctness so far that in the end no one is able to distinguish these diseases,” says Christian Drosten, a virologist at the University of Bonn, Germany.Naming diseases has long been a fraught process. Badly chosen names can stigmatize people, as did gay-related immune deficiency, an early name for AIDS. They can also lead to confusion and hurt tourism and trade. The so-called swine flu, for instance, is not transmitted by pigs, but some countries still banned pork imports or slaughtered pigs after a 2009 outbreak. More recently, some Arab countries were unhappy that a new disease caused by a coronavirus was dubbed Middle East respiratory syndrome.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Although “it’s usually scientists who come up with these names … the WHO gets the diplomatic pressure” if someone takes offense, Drosten says. The new guidelines, released 8 May, aim to smooth the process. “The WHO had to do something to take itself out of the firing line,” Drosten says.Given that news of a new pathogen often spreads quickly, “it is important that an appropriate disease name is assigned by those who first report” the disease, WHO’s guidance notes. Following the guidelines, it adds, could “minimize unnecessary negative impact of disease names on trade, travel, tourism or animal welfare, and avoid causing offence to any cultural, social, national, regional, professional or ethnic groups.”To that end, new disease names should not include geographic locations; the names of people, occupations, animals, or food; or “terms that incite undue fear” (such as unknown, fatal, and epidemic). Instead, the names should use generic descriptions of symptoms (respiratory disease or watery diarrhea) and specific terms describing patients, epidemiology or the environment (juvenile, maternal, seasonal, summer, coastal), as well as pathogen names and arbitrary identifiers (alpha, beta, 1, 2, 3).The group that came up with these recommendations met “more than a few times” over the course of a year, says Kazuaki Miyagishima, director for food safety, zoonoses, and foodborne diseases at WHO, and a member of the panel. Among the ideas they discussed: naming diseases after Greek gods, using a system similar to the one used to name comets or alternating male and female names as is done with hurricanes.”But while naming a hurricane Katrina may not offend people, if we do it for a disease, it’s not just a hurricane for 1 week. It will make its way into the history of human suffering,” Miyagishima says.The guide is well intentioned, but goes too far, says Ian Lipkin, a virologist at Columbia University. “I don’t see how it will be helpful to eliminate names like monkey pox that provide insights into natural hosts and potential sources of infection,” he says.It could also become harder to easily distinguish diseases. For instance, under the new rules, Marburg disease (named after a city in Germany) might have been called filovirus-associated haemorrhagic fever 1, while Ebola (named after a river) might have been filovirus-associated haemorrhagic fever 2. Such bland names “lose something that is more than just quaint,” says Howard Markel, a medical historian at the University of Michigan in Ann Arbor. Drosten adds that geographic names are sometimes justified. It was clear that MERS, for example, was associated with the Middle East. “Would it have been better if we had named it novel betacoronavirus clade C, type 1?” he asks.The new rules make for more difficult names, Miyagishima admits. “But we think we have left a fairly large area for freedom. We do not want to kill the creativity of researchers completely.”Linfa Wang knows all about the difficulty of naming diseases. Two decades ago, he named a virus and the disease it causes after Hendra, a suburb of Brisbane, Australia; he still gets angry calls from residents complaining that the name has hurt property values. These days his strategy is to “go small.” Recently, he named a new henipavirus isolated in a neighborhood called Cedar Grove simply Cedar virus.Virologists encountered other sensitivities with Norwalk virus, named for a city in Ohio. The pathogen is the only species in the genus Norovirus and usually that name is used. In 2011, however, a Japanese individual asked for a change because many people in Japan carry the surname Noro. The International Committee on Taxonomy of Viruses recommended using “Norwalk virus” instead.Acronyms are another good solution, says Ab Osterhaus, a virologist at Erasmus MC in Rotterdam, because they keep names short (another WHO recommendation) and people often forget what the letters stand for. But even acronyms can cause controversy. In 2003, WHO officials coined SARS (severe acute respiratory syndrome) to describe a novel pneumonia spreading in Asia, partly to avoid a name like “Chinese flu.” SARS did not go down well in Hong Kong, however, which is officially known as Hong Kong SAR, for special administrative region.Giving new diseases a number may be the only way to avoid such issues, researchers say. There is precedent. Growing up in China in the late 1960s, Wang remembers that diseases had digits. “I was really scared of number 5 disease,” he recalls. “I don’t know why, you just really did not want to get disease number 5.”
In Louisiana, a threatened natural history collection gets a reprieve By Rachael LallensackApr. 4, 2017 , 1:00 PM This plant specimen at the University of Louisiana in Monroe—and some 500,000 others—are looking for a new home. A Louisiana university’s collection of millions of fish and plant specimens no longer faces imminent destruction, but its ultimate resting place is still uncertain.Last week, a Facebook post from the natural history museum at the University of Louisiana in Monroe set off alarm bells within the science community. The museum faced “dark times,” the post noted, because university administrators had indicated that if staff couldn’t find an alternate location for the collection within 48 hours, it would need to be given away to a new institution—all to make room for a new running track and associated field. And if the collection wasn’t removed from campus by the end of July, it would be “destroyed.”The post was viewed 100,000 times, shared 1200 times, and generated more than 400 comments—as well as national headlines—before it was taken down at the request of university administrators. But with the attention, the darkness lifted. “Dozens and dozens” of other museums and academic institutions had offered to take in the collection’s 3 million to 6 million preserved fish, and some 500,000 plant specimens, says Thomas Sasek, a biology professor who also serves as the botany curator of the university’s natural history museum. As a result, “there’s no longer a danger of destruction,” he says, although the decision about exactly where to send the museum’s collection is still being finalized.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*) Thomas Sasek/University of Louisiana at Monroe It’s not the first time the museum, part of a small campus that serves about 10,000 students, has faced difficulties. Two biology professors—Neil Douglas and Dale Thomas—founded the collection decades ago. Douglas started collecting fish with his students in 1962, and Thomas added plants.After Douglas and Thomas retired, those who took over—including Sasek—had big shoes to fill. Shrinking university budgets complicated matters, often leaving curators shorthanded. The events that led to the collection’s recent near-death experience began in 2012, when the fish and plants were in storage, awaiting the renovation of a museum space. After a fire damaged a different academic building, administrators moved the collection to make way for classrooms. The specimens ended up in the university’s stadium, which has temperature controlled rooms and a sprinkler system. (The fish are stored in highly flammable alcohol.) But when the stadium was scheduled to get a makeover in August, the collection faced eviction.It is not an unfamiliar story in the museum community, which has seen other collections falter. “It speaks to a broader problem of this country,” says Robert Gopp, policy director at the Natural Science Collections Alliance, and interim director of the American Institute of Biological Sciences in Washington, D.C., and McLean, Virginia, respectively. “We are not investing in research infrastructure in a coordinated or thoughtful way.”Since 2009, Sasek has been able to win nearly $600,000 from the National Science Foundation to make digital pictures and other information about his plant specimens available to the public over the internet. Now, the collection’s impending move could complicate that project, which is part of a regional collaboration with other institutions. There is 18 months of work left to do, he says.For the moment, however, he and his colleagues are focused on the bittersweet process of figuring out who will get their collection, which he says “was the soul of our department.”
Shakib-Al-Hasan struck 101 and claimed 4 for 41 to steer Bangladesh to a facile 87-run win over Zimbabwe in the opening one-day international of the five-match series on Friday.Shakib became only the 12th cricketer in ODI history to claim a century and four or more wickets in a match.Zimbabwe were bowled out for 194 in 43 overs in response to Bangladesh’s 281 for 7. Brendan Taylor was the top scorer with 54 while Hamilton Masakadza made 42.Left-arm spinner Arafat Sunny (2 for 22), offspinner Mahmudullah (2 for 40) and fast bowler Mashrafe Bin Mortaza (2 for 33) picked up two wickets apiece. For Bangladesh, Mushfiqur Rahim scored 65 while debutant Sabbir Rahman knocked a fluent 44 not out.
Chennai, Sep 10 (PTI) A petition challenging a government notification in 2007 abolishing the parliamentary constituency of Pudukottai was today dismissed by the Madras High Court, which said the petitioner does not have any locus standi to challenge it as it is a registered body and not a voter. The first bench, comprising Chief Justice Sanjay Kishan Kaul and Justice T S Sivagnanam, while dismissing it, said it was relevant to point out that the petitioner is a Bar Association, a registered body comprising members who are advocates practising in the district. “Thus the petitioner association is not a voter and hence would not have locus standi to challenge the impugned notification as it cannot be construed as an aggrieved person. Therefore on this short ground, the relief sought for is liable to be rejected,” the bench said. Furthermore, the right to vote is a statutory right and not a fundamental right and in such circumstances, there can be no vested right for a voter to claim that he has a right to exercise his franchise in a particular constituency, it said. This would be another ground to reject relief sought for. The Association sought to quash the August 13, 2007 notification issued jointly by the Chief Electoral Officer and Secretary to Government, Public (Elections) Department, and Secretary, Delimitation Commission of India, in relation to abolition of this Parliamentary Constituency, as it stood in the draft notification and to direct the DC to restore it as one of the parliamentary Constituencies. The petitioner submitted that a major extent of present Revenue district of Pudukottai was an independent princely state and merged with the Union of India in 1948. After India became a republic, the first Parliamentary election was held in 1952. This parliamentary constituency was constituted as a separate one, though a major part of it was part of Tiruchirappalli Revenue district. In 1974, 4 taluks, including Pudukottai of Tiruchirapalli district and Aranthangi Taluk of Thanjavur district were carved out and the newly created Pudukottai district was formed, comprising five revenue taluks. The bench considered two issues — maintainability of the petition and whether the procedure contemplated under the Delimitation Act, 2002 was followed and opportunity was granted to place the objections. It said the plea raised was absolutely vague and the petitioner had not placed any material before the court to substantiate that deletion of the constituency was to protect the interests of the some individuals or political parties without naming such persons or entities. The bench said the Delimitation Commission has the power to rearrange constituencies, exercise of which must be assumed to be for good reasons and that the reasons assigned by the Commission for rearranging the constituencies after public hearings does not smack of any arbitrariness. PTI COR APR ZMNadvertisement
With the holiday season upon us, you may be busy attending a lot of events, visiting different places, meeting new people or perhaps even trying out some new activities. As you encounter every day with a fresh perspective, keep in mind that all of these experiences may be an opportunity to help you land a wonderful new job.Consider the story of Bernard Moitessier.If you don’t know who he is or what he did, read on, and consider how his experiences may connect to your own job search.First, we turn back time to 1968. When sailing legend, Bernard Moitessier, decided Cape Horn would be the most logical route for his return trip to Europe from Tahiti, he sat in the cabin of Joshua and reconciled this decision by listing what he believed were several cards in his favor.You see, ever since the first sailing ship ventured around the ‘Horn,’ its dangerous storms and unpredictable seas have been the source of many horrifying tales. So Bernard’s decision to return home this way was not made lightly.The ‘cards in his favor,’ as he put it were as follows:1) Joshua was practically indestructible since she was made of steel.2) She had an inside steering position. (Bernard added this feature while in Tahiti in anticipation of going around Cape Horn. He also added a dome above the steering position so he would have a 360-degree view of what was happening outside without having to endure the elements in this dangerous part of the ocean.)3) The steel construction of his boat meant that things would remain dry below decks, as opposed to the wooden craft that were prevalent at the time. (Fiberglass and ferrocement were also being used, but Bernard had very little faith in either of these construction materials for serious cruising sailboats.)4) Joshua had been constructed with ample fresh water storage, giving her crew the ability to remain at sea for up to five months without running out of fresh water. This was important because if his boat were dismasted, he and his crew could very well be drifting for quite awhile before they were found, especially in this part of the world.5) He would be able to benefit from the experiences of others. Bernard wrote, “All those who have rounded the Cape help others who come after them.”Bernard Moitessier had been sailing since he was old enough to push his first craft into a pond. His experience at the helm of a sailboat had gained him much notoriety by this point in his life. But, even armed with his own vast knowledge, he counted on the experiences of others who had rounded the Cape before him to be his most valuable asset.He even went so far as to say ” … those who failed often help more.”If, metaphorically speaking, you are preparing to round your own Cape Horn where your career is concerned, seeking the advice of a mentor or other professionals who have been where you are or are presently where you hope to be is a great way to better prepare yourself as you lay out your own course.The upcoming holiday season offers a variety of occasions to connect or reconnect with those who may have the experience you are looking for. From family get-togethers to corporate events, you never know whom you might bump into that could be a great source of information that may help you to steer clear of unknown hazards or help to better equip yourself and your career to deal with those hazards. Good luck to you this holiday season and beyond!
Bruce Buck has outlined plans for how Chelsea are pushing to win trophies in a sustainable manner, with rumours rife that owner Roman Abramovich is preparing to sell the club in the near future.Abramovich has halted his plans to redevelop Stamford Bridge with Chelsea, citing the reason as a “current unfavourable investment climate,” but it came on the same day that the Blues owner received Israeli citizenship after experiencing delays in getting his UK tier-1 visa renewed.The Russian oligarch has already invested well over £1 billion into the club and he is reported to want what would be a world-record price for a sport team of £3 billion to sell. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! Sources at Chelsea have denied the reports but they are not going away, with chairman Buck outlining his club’s updated strategy to become sustainable amid a backdrop of uncertainty.”It is developing, I think that we are all looking to be breaking even, and even be profitable, over the long term, but it is difficult,” Buck said at Leaders Sport Business Summit at Stamford Bridge. “The reason you have a football team is to win trophies, although there’s not a direct correlation, as winning trophies requires a lot of investment.”At Chelsea, we have worked very hard to push the sponsorship model. We have done everything we can to increase our matchday revenues and non-match day revenues at events like this. Most importantly, and we are at a crossroads, we are looking at media and broadcasting.”We are looking at the opportunities for the future to really make this club stable and profitable for the long term. Yes, we have central distribution for the main broadcasting revenues, but there’s lots of pieces that we can put together in terms of what’s going on in the world.”Disruption media broadcasting [including the likes of DAZN] and looking at other avenues to capitalise on the assets we have. The world is desperate for content. The world is even more desperate for live content. We have that.”We are looking at things like Dugout, which you might be aware of, and other things to try to increase the revenue base going forwards.”Chelsea caused major disruption in European football when Abramovich took over the club in 2003, as they entered the top level of the transfer market and established the dominance of bigger clubs.They have since won every major honour and become England’s most successful club during the Abramovich era. Buck believes it is impossible for any club aside from Manchester City to replicate what Chelsea did and that the drawbridge has been brought up on new clubs with wealthy owners being able to compete at the top level.“There are 10 or 12 big clubs in Europe right now and I think five to 10 years from now, in round terms, those 10 or 12 clubs will be the big clubs then,” Buck added. “The mix in terms of who’s on top, with respect to revenue, performance and trophies, that is up for grabs.“The dream in England is, if you support a Conference team, someday you’ll win the Premier League. Financial Fair Play has pluses and minuses. One of the minuses is that dream is not possible. What Chelsea did in 2003, what Man City did five years later, that is virtually impossible under FFP.“In terms of competitive balance, which is always viewed in a negative way, I personally believe that, for the development of football, marquee clubs and marquee players are important. It’s important in developing fanbases, encouraging young people to engage in this sport, and it’s also important in terms of the large clubs having the ability to put a lot of money into good causes, which they do.“I’m not in favour of dumbing down the large clubs to make all clubs the great unwashed. They’ve done that in the US over the last 20 years and I think it’s been to the detriment, particularly of baseball.“I just don’t think it works for the long term. Clubs have to seek their natural position in the football order. No matter where you are in that, you want to improve, but I don’t think we should assume that, because every club is not equal, therefore it’s bad.” Check out Goal’s Premier League 2019-20 fantasy football podcast for game tips, debate and rivalries.
Read Part One This post continues our new How Did You Handle…? series—specific how-tos based on your experiences. There’s still time to make productive changes to your year-end appeal! Here are more year-end campaign change-ups, attempted for the first time this year by some of your fundraiser peers (with early results where available).1. Change-Up: Launching matching gifts for first-time donors (including those coming in on #GivingTuesday).We secured two donors—one who is an absolutely new donor—to offer a dollar-for-dollar match (up to $1,000) for all first-time donors. We are also offering a separate $500 match to new online donors on #GivingTuesday.As director of development, I pushed the match approach and found supportive donors. I was thrilled when our executive director jumped on board and found a matching donor for #GivingTuesday.But that’s not all. Our executive director pledged a $500 gift if all staff members contribute to the campaign. Great news: Our board is already at 100%!Goal: I had used the matching challenge in other types of campaigns and found it highly successful in increasing the number of new donors and total gifts. We’re hoping to achieve the same value this year. We’ll keep you posted! Results to Date: Just starting our year-end campaign (our executive director hand-signs all appeal letters and adds personal notes to many of them).Source: Alan Gibby, director of development, Shelter Care Ministries2. Change-Up: Revising our channel and format mix for year-end appeals to include direct mail for prospects who don’t read our emails.After digging into our email database statistics, we noticed that many of our donors don’t check their emails. Direct mail is our best hope for engaging these folks; this way we know they’ll receive an appeal. We’re sending them our first-ever direct mail appeal.Goals: We hope to strongly encourage our consistent donors to increase their gifts and reactivate our lapsed donors.Source: Kiki Fornito, development associate, Build ChangeNote from Nancy: Other fundraisers reported very different changes in their year-end channel and format mix:· “We are moving to an 80-20 split between email and direct mail outreach to members in our fundraising campaigns; the goal is to convert members to donors. Early results are positive,” reports Laural Bowman, political affairs manager with the Ohio State Medical Association.· “We are reaching out via phone to donors as a supplement to our direct mail year-end campaign. Of course, we’re tracking what impact these calls, which are low cost but labor intensive, have on results, and we’ll use that data to fine-tune next year’s year-end approach,” says Jayme Hayes, president of Junior Achievement of the Eastern Shore.Whatever your organization’s mix, the crucial takeaways are to always look hard at response patterns to year-end and other fundraising campaigns and to do more of what’s working and less of what isn’t.If one of these approaches makes sense for your organization—based on data and anecdotes, not just gut instinct—see if there’s at least some small way you can incorporate it into remaining elements of your year-end campaign. It just might make a difference!With refreshing practicality, Nancy Schwartz rolls up her sleeves to help nonprofits develop and implement strategies to build strong relationships that inspire key supporters to action. She shares her deep nonprofit marketing insights—and passion—through consulting, speaking, and her popular blog and e-news at GettingAttention.org.
Posted on March 13, 2014August 10, 2016Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to email this to a friend (Opens in new window)Click to print (Opens in new window)One aspect of the Maternal Health Task Force’s mission is to increase access to critical maternal health information and evidence. We know that language can be a barrier to access, especially since the scientific literature is primarily in English.As part of our information outreach efforts, we would like to learn more about the need for maternal health information in languages other than English.We are currently conducting a short survey to learn more about the maternal health community’s translation needs. We recognize the limitations of this survey given that it is in English. However, if you could think about the needs of your colleagues, that would be extremely helpful.Please let us know your thoughts!Take the survey now: https://harvard.qualtrics.com/SE/?SID=SV_81Um1cyLslyF5L7Share this: ShareEmailPrint To learn more, read:
GAINESVILLE, FL – NOVEMBER 03: A Florida Gators cheerleader performs during the game against the Missouri Tigers at Ben Hill Griffin Stadium on November 3, 2018 in Gainesville, Florida. (Photo by Sam Greenwood/Getty Images)The biggest college football game on Week 6’s slate is taking place in Gainesville, Fla.Florida, the No. 10 team in the country, is hosting No. 7 Auburn at Ben Hill Griffin Stadium. ESPN’s College GameDay will be in town for the game.The Tigers are going into the game as the favorite and the betting line has already shifted.Auburn and Florida opened as a “pick’em” game, but the bettors seem to like the Tigers. The betting line is already up to Auburn -3. There’s a new No. 1 in the latest AP Poll!@SEC teams in the Top 25:1) Alabama3) Georgia5) LSU7) Auburn10) Florida25) Texas A&M— SEC Network (@SECNetwork) September 29, 2019This is the biggest game of the SEC season to date.It’s not necessarily a College Football Playoff elimination game, as both teams are undefeated, though the loser will have a major uphill battle.Both Florida and Auburn have several big games remaining.The Gators and the Tigers are set to kick off at 3:30 p.m. E.T. on CBS.
Former #Texas coach, recruiting coordinator and administrator Ken Dabbs has passed away.Below is a statement from #Longhorns Head Coach Tom Herman. pic.twitter.com/CsxXN5aymZ— Emily Giangreco (@EmilyGiangreco) October 17, 2019Prior to joining Texas’ staff in 1973, Ken Dabbs became Austin (Texas) Westlake High School’s first football coach and athletic director. Four years later, he earned a job with Texas. Westlake is now a major college football pipeline, producing current Longhorns Sam Ehlinger, Jake Ehlinger, and Doak Wilson.Dabbs is survived by Marguerite, his wife, three sons, six grandchildren and seven great grandchildren.Westlake Presbyterian will host his funeral services on Oct. 25.Many consider Dabbs a great friend and special person. He was best known for his story-telling and friendly personality. When recruiting Campbell, Dabbs offered a friendship rather than other incentives and tactics.He will be missed. But his Texas legacy will most certainly live on.[Emily Giangreco] BOULDER, CO – OCTOBER 04: A helmet of the Texas Longhorns lies on the field as the team warms up prior to facing the Colorado Buffaloes at Folsom Field on October 4, 2008 in Boulder, Colorado. Texas defeated Colorado 38-14. (Photo by Doug Pensinger/Getty Images)Former Texas Longhorns recruiting coordinator Ken Dabbs passed away on Wednesday night at the age of 84. Prior to his passing, the legendary Texas recruiter had a lengthy hospital stay before coming home to be surrounded by family.Perhaps Dabbs’ most notable football achievement was recruiting eventual Heisman winner Earl Campbell. He was tasked by then-head coach Darrell Royal to do all he could to land the talented running back.Dabbs even stayed 17 consecutive nights at an inn close to Campbell’s childhood home to stay in touch with him. Not only did his efforts prove successful — Campbell turned out to be the best player in Texas history.Current head coach Tom Herman put out a statement after Dabbs’ passing, reflecting on what he means to the Longhorns football program:
There has been a seismic shift at Paris Saint-Germain. Where once the plan was to build a dynasty with Neymar as the centrepiece, the reality this summer is very different.To sell Neymar – either back to Barcelona or on to Real Madrid – was once unthinkable in the eyes of club president Nasser Al-Khelaifi. Now, it seems inevitable.Too much appears to have passed between Neymar and PSG; his time in the French capital – despite two Ligue 1 titles and a host of individual trinkets – has been a washout. Article continues below Editors’ Picks What is Manchester United’s ownership situation and how would Kevin Glazer’s sale of shares affect the club? Ox-rated! Dream night in Genk for Liverpool ace after injury nightmare Messi a man for all Champions League seasons – but will this really be Barcelona’s? Are Chelsea this season’s Ajax? Super-subs Batshuayi & Pulisic show Blues can dare to dream He never became that transformative figure the club so desperately required to take the next step.And now the club will no longer indulge him; the message being if you don’t want to be here, then leave.From his seeming indifference to middling league games to his chronic injury trouble – which put paid to both his Champions League campaigns in PSG colours at the last-16 stage – something always got in the way, preventing Neymar from becoming the undisputed hero in the eyes of PSG supporters.And their first home game of the Ligue 1 season – last week against Nimes – brought with it a shocking spectacle. PSG ultras carried banners in the stands and sang songs severely criticising Neymar, labelling him a mercenary and demanding his immediate dismissal from the squad.The message was that his heart was never in it, something that became all the more apparent when he recently labelled the Remontada – Barcelona’s stirring Champions League comeback against PSG in which Neymar was the protagonist – as one of the best moments of his career. That was taken as the ultimate display of disrespect for the club which pay him – handsomely – but one which he still cannot bring himself to love.Neymar has absented himself from humdrum matches with minor injuries and was reported AWOL this summer having failed to return from Brazil following yet another foot injury.He punched a fan after Rennes beat them in the cup final at the end of the season, and has got himself into trouble for messages sent on his Instagram account following PSG’s elimination from the Champions League by Manchester United.From a Ballon d’Or winner-in-waiting, Neymar now conjures trouble, more perhaps than it’s worth. And the question Real Madrid and Barcelona might well find themselves asking right now is whether or not Neymar is merely in a slump of his own making or is genuinely on the decline.He has been usurped by Kylian Mbappe – the local boy champion – who ended last season demanding more responsibility at PSG or else he would go and find it elsewhere.PSG are thought to be particularly spooked by the idea of Mbappe decamping for Manchester City, whose manager Pep Guardiola is a long-time admirer.Mbappe is a player PSG should build around for the decade to come and will be in line for a substantial pay-rise once Neymar leaves.On the surface, it looks similar to the situation Guardiola had in his in-tray when taking the Barcelona job in 2008, involving Ronaldinho and Lionel Messi.Ronaldinho had helped Barcelona reclaim their perch as one of the best teams on the continent having joined in 2003 from PSG.Under Frank Rijkaard, he had led Barca out of a six-year trophy drought and to two Liga titles, the 2006 Champions League and had secured the Ballon d’Or for good measure. He was – for a time – the best player the game had ever seen.But Ronaldinho – even though he was only 28 – was widely seen to be on the wane. His powers were diminishing, as the late nights and his own inimitable easy-going lifestyle clashed head-on with the demands of life as an elite sportsman.And, crucially, Barca also had Messi coming to prominence. While the two were and remain close friends, there was only going to be space for one of them as the fulcrum of Guardiola’s new-look Barca team.Ronaldinho helped nurture Messi to greatness and revealed to all and sundry that the little Argentine would surpass him as a player.And so he passed the baton to Messi, departing for AC Milan. He would never again achieve the heights he hit at Barca and wound down his career with only intermittent flickers of greatness from there on out.Messi, of course, has gone on to achieve countless honours, the best player Barcelona has ever seen and, arguably, the best player ever full stop.PSG find themselves at a similar crossroads; with the option to get rid of their landmark Brazilian superstar and leave control of the team at the feet of their promising young steed.The big difference? Neymar has got nowhere near Ronaldinho’s level, in terms of influence, legacy or trophies. No Ballon d’Or, no Champions League, nothing, in fact, out of the ordinary.And he will go not with affection from PSG fans but with a sense of what could have been.
Jadon Sancho has become the youngest player in Bundesliga history to score 15 goals in the league, breaking a half-century old record.The 19-year-old attacker continued to cement his status as one of the league’s best players as he delivered the equaliser for Borussia Dortmund against Cologne in the club’s second match of the season Friday.A first-half goal from Dominick Draxler had put the hosts up, but Sancho’s 70th minute goal, assisted by Thorgan Hazard, helped turn the tide in the contest. Article continues below Editors’ Picks What is Manchester United’s ownership situation and how would Kevin Glazer’s sale of shares affect the club? Ox-rated! Dream night in Genk for Liverpool ace after injury nightmare Messi a man for all Champions League seasons – but will this really be Barcelona’s? Are Chelsea this season’s Ajax? Super-subs Batshuayi & Pulisic show Blues can dare to dream Achraf Hakimi would find the back of the net 16 minutes later to give Dortmund the lead while Sancho chipped in again late on, assisting Paco Alcacer’s stoppage time insurance tally to give the visitors a 3-1 victory.That brings Sancho’s total up to two goals and two assists already in the new season as he picks up from where he left off last campaign.Last season saw Sancho score 12 goals and add 14 assists in the league as he helped Dortmund to a title challenge that saw them take the race all the way to the final matchday of the season, though they fell short to Bayern Munich.Added to his single Bundesliga goal in his debut season of 2017-18, Sancho is now up to 15 in the German top-flight, surpassing the record set by Horst Koppel in 1967.Koppel, who starred at the time for Stuttgart and was head coach at Dortmund from 1988 through 1991, was 19 years and 185 days when he reached 15 goals, whereas Sancho has managed it at just 19 years and 151 days.19y 151d – @Sanchooo10 (19y 151d) is the youngest player in #Bundesliga history to score 15 Bundesliga goals, beating the record of Horst Köppel from 1967 by 34 days. Wunderkind. #KOEBVB @BlackYellow pic.twitter.com/TY1f3pJSsi — OptaFranz (@OptaFranz) August 23, 2019 Overall, Sancho has scored in his last three Bundesliga matches dating back to last season, and has six goals in his last eight league contests.The former Manchester City academy player’s stock continues to rise as he lights up Germany, with reports saying many of Europe’s biggest clubs are interested in prying him away from the Bundesliga runners up.Sancho will look to continue his scoring streak, as well as make it three wins from three matches for Dortmund, when he and the club face Bundesliga returnees Union Berlin on August 31.
Napoli defender Kalidou Koulibaly was left devastated by his injury time own goal that saw his side lose 4-3 to Juventus on Saturday.Juve took a 3-0 lead thanks to goals from Danilo, Gonzalo Higuain and Cristiano Ronaldo, but the visitors fought back, with Kostas Manolas, Hirving Lozano and Giovanni Di Lorenzo finding the net to pull level with the reigning Serie A champions.With just 90 seconds left, however, Koulibaly tried to clear a cross from a free-kick and ended up knocking it past Alex Meret to hand the hosts three points. Article continues below Editors’ Picks What is Manchester United’s ownership situation and how would Kevin Glazer’s sale of shares affect the club? Ox-rated! Dream night in Genk for Liverpool ace after injury nightmare Messi a man for all Champions League seasons – but will this really be Barcelona’s? Are Chelsea this season’s Ajax? Super-subs Batshuayi & Pulisic show Blues can dare to dream And the centre-back spoke of his disappointment after the game, but he remains confident his side can bounce back.”It’s an own goal that hurts me because it came after an incredible comeback,” the 28-year-old said on Twitter.”I’m sorry but I have to, we have to accept it: we are strong. We have shown that. We’re going to prove it.”Coach Carlo Ancelotti was not happy with his side’s display, despite their incredible turnaround in the second half.”It was not a positive performance. The first hour we didn’t do well. But despite the 3-0 we stayed in the game, we came back,” he said.”But my judgment would not have changed even with a 3-3 draw.”Juventus played more on the counterattack at 2-0 and we had more control over the game, we gave Juve the chance to press and take confidence. “We made so many mistakes, allowing them to press, to create problems, to show courage.“Blaise Matuidi, for example, did an extraordinary job, but left room for Fabian Ruiz who remained isolated. We never managed to get to him with a clean pass. Too bad, the spaces were there.”He added: “Juventus have so much character and quality, we know that they always step up in the important moments of the season. “We wasted an opportunity today.Napoli are in action again on September 15 when they host Sampdoria, the same day Juventus visit Fiorentina.
The tagline for FIFA 20 is ‘Break New Ground’ and that is what EA Sports claims to do with the newest update of the annual football game, adding street and indoor football after years and years of appeals and demands from fans of the game.Between 2005 and 2012, they released four versions of FIFA Street, which had been a standalone series released alongside the regular iterations of FIFA.FIFA 20 review: Volta footballThe new Volta Football mode in FIFA 20 attempts to bring the hugely-popular FIFA Street series to the mainstream and this is where the main changes of the game lie from last year’s FIFA 19. Article continues below Editors’ Picks Ox-rated! Dream night in Genk for Liverpool ace after injury nightmare Messi a man for all Champions League seasons – but will this really be Barcelona’s? Are Chelsea this season’s Ajax? Super-subs Batshuayi & Pulisic show Blues can dare to dream Time for another transfer? Giroud’s Chelsea spell set to end like his Arsenal career Volta uses the same match engine as the regular game with three-on-three, four-on-four and five-on-five matches included.It also picks up the mantle of the game’s story mode following the Journey from FIFA 17 through FIFA 19 and allows you to create your own custom player to progress from an amateur to being the best futsal and street footballer in the world.Fans of the Journey will enjoy Volta’s storyline, improving their player’s stats and customising them with different looks and outfits as they progress, but casual fans can still play indoor football through kick-off mode and ignore the storyline altogether if they so wish.It’s an enjoyable alternative to the regular 11-vs-11 matches using licensed clubs from all over the world, but for many FIFA Street fans, it lacks the warmth and spontaneity of the original series.For most, the novelty of Volta will probably wear off once they have completed the story or played a few games and will return to the standard game modes that have been popular in the past.FIFA 20 review: Ultimate TeamFIFA Ultimate Team (FUT) has long been the most popular part of every FIFA and this year’s sees the menu system get an overhaul as well as rewards and objectives.Players can earn XP from playing more matches, buying and selling players, completing challenges and more which gives rewards through Season Objectives.FUT Champions Weekend League and Divisions Rivals remain the same as last year, while the offline Squad Battles mode has been slightly tweaked to allow players to refresh their opponents when they want rather than having to wait 24 hours for a new batch of teams to take on.These small tweaks are nice improvements to FUT and follow the mantra of if it isn’t broken, don’t fix it.FIFA 20 review: Is Career Mode broken?However, something that has been broken in the update to FIFA 20 is Career Mode.Bugs in the initial release have seen AI managers field weakened teams, causing fans of the game to take to Twitter where their reaction saw the hashtag #FixCareerMode trend in the UK.In the first two patches of the game since launch, these bugs have not been fixed, further annoying fans as these bugs should have been noticed in testing before FIFA 20’s release.FIFA 20 review: Best of the rest & gameplayOnce again, the game impresses with its level of licensing, having over 700 teams from 30 leagues around the world, including the Romanian Liga I for the first time ever.The Champions League, Europa League and Super Cup remain from last year, but Juventus are not licensed in FIFA 20 and are called Piemonte Calcio in all modes of the game, with the commentators never referring to them by name.Gameplay features updates and improvements from previous years, which means anyone who has played FIFA 18 or FIFA 19 can easily pick it up and be competitive straight away.The biggest change to gameplay is with set-pieces, with free-kicks now more intuitive while penalty kicks now use timed finishing and can be incredibly rewarding or frustrating – much like a real-life penalty shootout.VAR has not been introduced while short goal kicks are missing from FIFA 20. However, these are minor complaints for a game which has attempted to make proper progress this year.Once the Career Mode issues are fixed, it will become an essential purchase yet again, especially if you are willing to spend time to fall in love with Volta.FIFA 20 review verdictIt hasn’t broken new ground as promised, but FIFA 20 delivers an exciting update from FIFA 19 and will please the majority of football fans once again.FIFA 20 review score: 7.5/10