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Designer protein halts flu Eva-Maria Strauch By Robert F. ServiceJun. 12, 2017 , 11:15 AM There’s a new weapon taking shape in the war on flu, one of the globe’s most dangerous infectious diseases. Scientists have created a designer protein that stops the influenza virus from infecting cells in culture and protects mice from getting sick after being exposed to a heavy dose of the virus. It can also be used as a sensitive diagnostic. And although it isn’t ready as a treatment itself, the protein may point the way to future flu drugs, scientists say.“It’s impressive,” says James Crowe, an immunologist at Vanderbilt University in Nashville, who was not involved in the study. But because it hasn’t yet been tested in humans, “it [still] has a long way to go,” he says.Influenza severely sickens 3–5 million people each year, and it kills between 250,000 and 500,000, mostly the elderly and people with weakened immune systems. Every year, public health officials survey the three flu subtypes circulating in humans and design a vaccine for the next winter season that covers them all. 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Most focus on the proteins on the virus’s outer coat, neuraminidase and hemagglutinin (HA). Some drugs that block neuraminidase, which helps the virus escape already infected cells, are starting to bump up against viral resistance. HA is scientists’ next target. The mushroom-shaped protein specializes in infecting cells, first by binding a trio of sites on its head to three separate sugar molecules on the surface of targeted cells. Once the virus latches on, parts of HA’s stem act as a grappling hook to pull the virus in close, allowing it to fuse with the cell membrane and release its contents inside.In 2011, researchers led by David Baker, a computational biologist at the University of Washington in Seattle, created a designer protein that binds HA’s stem, which prevented viral infection in cell cultures. But because the stem is often shrouded by additional protein, it can be hard for drugs to reach it.Now, Baker’s team has designed proteins to target HA’s more exposed head group. They started by analyzing x-ray crystal structures that show in atomic detail how flu-binding antibodies in people grab on to the three sugar-binding sites on HA’s head. They copied a small portion of the antibody that wedges itself into one of these binding sites. They then used protein design software called Rosetta to triple that head-binding section, creating a three-part, triangular protein, which the computer calculated would fit like a cap over the top of HA’s head group. Next, they synthesized a gene for making the protein and inserted it into bacteria, which cranked out copies for them to test.In the test, Baker’s team immobilized copies of the protein on a paperlike material called nitrocellulose. They then exposed it to different strains of the virus, which it grabbed and held. “We call it flu glue, because it doesn’t let go,” Baker says. In other experiments, the protein blocked the virus from infecting cells in culture, and it even prevented mice from getting sick when administered either 1 day before or after viral exposure, they report today in Nature Biotechnology.Despite these early successes, Baker and Crowe caution that the newly designed protein isn’t likely to become a medicine itself. For starters, Baker says, the protein doesn’t bind all flu strains that commonly infect humans. That means a future drug may require either a cocktail of HA head group binding proteins or work in combination with stem-binding versions. Second, the safety of designer proteins will have to be studied carefully, Crowe says, because they are markedly different than natural HA-binding antibodies. “The further you get away from a natural antibody, the less you can predict what will happen,” Crowe says.But down the road, Baker says, the new designer protein could serve as the basis for a cheap diagnostic—akin to a pregnancy test—for detecting flu and possibly even medicines able to knock it out. A designer protein (brown and orange) fits snugly on top of the influenza virus’s hemagglutinin protein (green), which helps the virus latch onto and infect cells.
President Antonio Percassi said Atalanta are too “poor” to bring Zlatan Ibrahimovic to Bergamo, but claimed they are “expecting to qualify” for the next phase of the Champions League. La Dea have rocketed to the top of Italian football these last few years, but the President said they are still “grounded” and yet ambition, despite picking up one point from the first four Champions League games. “We expect to advance in the Champions League,” Percassi told news agency ANSA at the inauguration of the Mino Favini Academy. “The second half against Manchester City was amazing, that’s why we believe in it.” The news about Ibrahimovic leaving MLS has sparked an interest from a host of Italian clubs, linking Napoli, Milan and Bologna to the player. Percassi won’t entertain any rumours of the Swedish star moving to Bergamo, though. “Ibrahimovic is a great player, but we can’t afford him,” the 66-year-old added. “We are mere paupers… “We don’t have the revenue of the big clubs, although miraculously we get the results and remain a provincial reality keeping our feet on the ground. “We can’t compete with certain figures. We’ve got clear ideas regarding the stadium and have to complete the Zingonia training centre. We still need some millions and we have already spent €4m on the Bortolotti Center.” He might free up some spending money if he decides to sell Dejan Kulusevski, who has been attracting interest after his performances at Parma this season, but the President doesn’t seem to be in a rush. “We will evaluate at the end of the season, and we will do it on our own terms.” Before facing Dinamo Zagreb in the Champions League, Atalanta must prepare to face Juventus in Serie A when they are back in action after the international break. “They will be two great matches, since they are two great teams,” he said. “It’s important to have [Duvan] Zapata back, we have missed him.” Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/
Advertisement AdvertisementReal Madrid welcomed the second coming of Zinedine Zidane as manager with much pomp at the tailend of the season. The manager deemed their campaign already over, as he now prepares for the oncoming season, and with star defender Rafael Varane linked with a move away from Spain, Real have offered a pay raise in order to convince him to stay. Varane, who is seriously valued not only by Real but also by Zidane, is linked with a move away from the Spanish capital this summer, as he enters the final two years left on his present 4-year contract he signed in 2017.Bundesliga champions Bayern Munich will be hoping to add the World Cup winning centre-back to their aging squad, while Serie A champions Juventus, facing an identical problem, will be aiming to bolster their backline as both Chiellini and Bonucci aren’t growing any younger. Meanwhile, Ole Gunnar Solskjaer hopes to rejuvenate a revived Manchester United squad for the upcoming season and has his eyes firmly set on Varane.The 25-year old French international, who is valued at €80m, is on a €6m a year fee. And as Zidane hopes to make a fresh start next year, neither he nor the club wish the defender to leave. French media outlet L’Equipe report that the Los Blancos will try to entice him to stay by offering him a pay raise which will see his wages rise upto €9m a year.However, should Varane decide against staying, the European champions are said to have found a perfect alternative in highly rated Napoli defender Kalidou Koulibaly.Above all, Ligue 1 champions Paris Saint-Germain are said to be leading the race to sign the defender.Read also:-Adrien Rabiot ‘agrees’ to move to Real Madrid – reportsZinedine Zidane hints that he would like to have Paul Pogba in his Real Madrid squad
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Zlatko Dalic believes playing at Wembley will be motivation enough to ensure fatigue does not derail Croatia against England in the Nations League on Sunday.Croatia were involved in a pulsating 3-2 win over Spain on Thursday – a result which means all three teams are in the race to qualify from Group 4 of League A going into the final match.A win for England or Croatia would guarantee promotion a place in the Nations League Finals, but the prospect of relegation also looms for both sides. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! Dalic admits that the win over Spain took a lot out of his players but is confident that playing in a stadium as iconic as Wembley will give his side the lift they need.”We are tired,” said the coach. “Kick-off is at 2pm, which is not the best. But what can we do? We will try to make it a spectacular day.#Croatia head coach a day before #NationsLeague decider #BeProud #Vatreni pic.twitter.com/Kh4uM6GUcL— HNS | CFF (@HNS_CFF) November 17, 2018″I hope we can be totally fit and we can play at our best.”It was not easy [against Spain], but to play against England at Wembley means we are motivated.”Sunday’s clash is the third time the two sides will have met this year, following Croatia’s World Cup semi-final win in Russia and the goalless draw in last month’s reverse Nations League fixture in Rijeka.Dalic, though, insists the rivalry is friendly and that he will not take extra measures to combat forward Raheem Sterling, who lit up England’s win over Spain last month with two goals.”Both teams know each other,” he added. “It’s a positive atmosphere and rivalry on the pitch. We beat them in the semi-final of the World Cup, which was the most important result.”We know what we have to do. They don’t only have Raheem – they have a lot of fast players. It’s a large pitch and they have strong and fast players.”Winger Ivan Perisic – who scored Croatia’s equaliser in their World Cup win over Gareth Southgate’s men – believes if his side play to their full capability, they will emerge victorious.”It’s difficult to say who is the favourite,” he said.”You can expect a really tight match, but if we play to our best, we can win the match.”
While Venezuela’s Under-20 team were preparing for Monday’s daunting South American Championship clash against Brazil, back in Caracas a rather more serious battle was unfolding.Just 12 hours before the young Vinotinto hopefuls kicked off in Chile a group of dissident soldiers took up arms in what appeared to be the beginnings of an abortive coup d’etat, the latest chaotic episode to afflict the crisis-ridden South American state.After stealing military equipment, those involved recorded a video denouncing President Nicolas Maduro’s “regime, which we absolutely do not recognise”, before calling on the citizens of Venezuela to join their uprising. They were quickly apprehended by forces loyal to Maduro, but the underlying issues that have seen Venezuela descend into economic ruin and violent political upheaval continue to fester. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! Against that backdrop, however, the nation’s youth teams continue to thrive, as the stars of tomorrow, dispersed across the world or fighting to survive back home, battle on an equal footing with football’s traditional giants in South America and across the world.The origin of Venezuela’s crisis is disputed. For followers of Maduro’s government the fault lies with an economic boycott imposed by dominant business groups across the country, which has led to a shortage of foodstuffs and other consumer goods and has been compounded by an openly seditious opposition backed by hostile foreign powers.Opponents, meanwhile, point the finger at alleged economic incompetence and the squandering of billions of dollars in oil revenue by the president and his predecessor, the late Hugo Chavez, and accuse Maduro of trying to install a communist dictatorship. Such vehement hatred between the two sides has led to widespread political violence: in 2017 clashes between the president and the opposition-dominated National Assembly spilled out on the streets of Venezuela, leaving an estimated 165 dead and over 15,000 injured.At its heart, though, the issue is predominately economic. Venezuela is mired in hyperinflation, with private estimates placing the annual rate at an almost unfathomable 830,000 per cent. This has had a catastrophic effect on poverty rates, which after falling sharply under Chavez are now said to be close to 90%. The crisis has also provoked its own humanitarian disaster, prompting an estimated 1.6 million Venezuelans to emigrate in the last three years alone and, according to some observers, as many as four million over the last 10 years.Violent crime is also epidemic. Statistics show that in the world only Central American states El Salvador and Honduras suffer more homicides per 100,000 people than the country, while robberies and kidnappings are also a daily hazard for citizens.Football, of course, has also suffered during this economic and social meltdown. And while the biggest clubs can stave off disaster thanks to the injection of US dollars provided by television and participation in competitions such as the Copa Libertadores, those closer to the grass-roots teeter on the brink.“The worst affected are the youth divisions, there are serious deficiencies in training equipment, with the lack of food and because of emigration,” Alfredo Coronis, a journalist in Venezuela with Deportivo 1300AM , explained to Goal . “There are talents who look promising at 14, 15 and then they leave the country to work in a store. The crisis has also affected transport, the airlines have closed down and there are no spare parts for buses or other vehicles. That affects clubs’ development.”Wilson Gutierrez, a Colombian coach who took the reins at Carabobo FC in 2018, also laid bare the brutal realities even for a player at the top of the game in the country. “We didn’t have many things. There were times that some players did not receive their salaries,” he explained to El Espectador.“Let’s say that a Venezuelan footballer who’s been playing for three or four years and is quite well-known can earn between US$300 (£230) and US$400 (£310) a month, while others earn $80 (£60) to $100 (£80), it is really not enough. There are even some who get paid in [local currency] bolivares and there are also delays in payment.”Gutierrez was accompanied to Venezuela by fitness coach Gustavo Bustos, who suffered two carjacking attempts in less than a year while travelling with the team. Such attacks are common: in the most notorious case, in September 2016, the team bus of Trujillanos was stopped by armed assailants, who relieved the players of cellphones, money, sporting equipment and even their shirts and shoes as well as the bus’ DVD player.Carlos Bustamante, a Venezuelan who works in London as a reporter for talkSPORT , believes that the fear of such attacks can affect players as much as material shortages.Trujillanos, equipo de Primera División de Venezuela, fue asaltado en bus que lo trasladaba https://t.co/TOQPUSl8ji pic.twitter.com/bghR0Zd79k — Win Sports (@WinSportsTV) 20 de septiembre de 2016 “Personally players might face moments where their family or friends are affected which results in a loss of concentration and this type of psychological issue is very difficult to overcome,” he explained.Paradoxically, almost miraculously, the top level of Venezuelan youth football has never been better. Coached by Rafael Dudamel, who also directs the senior team (a sign itself of how importantly the category is seen in the country), the Under-20s finished as runners-up in 2017’s World Cup, losing out only to England in the final after beating the likes of Mexico, Germany, the United States and Uruguay in a memorable tournament.The 2019 team is similarly making waves. After beating Colombia and hosts Chile to start the South American Championship in perfect fashion the Vinotinto were unlucky to go down 2-1 to powerhouses Brazil, with Santos’ future Real Madrid star Rodrygo scoring twice against the run of play. Despite that setback, Dudamel’s men are almost assured a place in the six-team final stage, with a win against Bolivia in their final group A fixture on Wednesday guaranteeing qualification.For so long a football backwater, the sport being a poor relation to the dominant baseball, the Vinotinto are now considered worthy rivals by their South American cousins.“Sport has for a long time been the main way to achieve social mobility,” Bustamante points out. “First it was baseball and since the tenure of Richard Paez as Vinotinto coach football has also become a way out. The amount of talented youngsters who at first were from poorer backgrounds, but who now also come from the middle classes and hope to be discovered is incredible.”Coronis, meanwhile, points to tentative efforts by the Venezuelan Football Federation to develop young talents, with clubs in Primera obliged to pick at least one U-20 player in each game and also to field teams in the U-17 Copa Venezuela. He also highlights the influence of Dudamel: “Since Venezuela did not qualify for the  World Cup he has placed a lot of importance on the U-20s, without neglecting the seniors. But it is a process that goes back through Cesar Farias and Richard Paez, although Dudamel is now having success.”The presence of overseas players in the Vinotinto squad is both a symptom of the country’s ills and a boon for its footballing future. With eight players based outside Venezuela the U-20 squad trails only Uruguay in counting on foreign-based talent; while the previous World Cup served as a shop window for stars like brilliant goalkeeper Wuilker Farinez – now in Colombia with Millonarios – Argentina-based attacking pair Jan Hurtado and Samuel Sosa and current captain, Juventus youth defender Christian Makoun, to move away from their home countries in search of stardom.The case of Sosa, one of the stars of the South American Championship so far, is emblematic. Having made his debut with local heavyweights Deportivo Tachira at just 16, the playmaker swapped Venezuela for Argentina at the start of 2018 days after his 18 th birthday. He is yet to break into the Talleres squad in the Superliga, but two brilliant free-kick goals in Chile against Colombia and Brazil have only raised his stock.“I would never speak ill of my country,” the youngster stated in a 2018 interview with La Nueva Manana , while recognising the problems Venezuela faces. “Venezuela will move forward. I was lucky enough to get out of my country and I thank God for that but I have people close to me who are suffering.“I have my parents there, they live in the Tucuyito neighbourhood in Valencia and they are humble. Right now they will live off the money I can send from Argentina. I came alone, soon my girlfriend will arrive and I hope to bring my family to live with me over the next few months.”“There is no doubt that the mere fact that you are improving your quality of life means that you have a better chance of developing your talent,” Bustamante argues. The exodus of Venezuelans, however, has not come without its risks for young players. With emigration centred in neighbouring Colombia as well as other South American nations, xenophobia towards nationals has become a focus for concern.During the Vinotinto’s win over Chile the hosts’ Nicolas Diaz, reacting to a strong tackle from Pablo Bonilla, called the right-back a “muerto de hambre”, literally a starving man, in reference to his country’s crisis. Diaz later apologised for his remarks, and the flip side of that unsavoury incident has been an explosion of support for Sosa, Bonilla and Co. in the stands at every Venezuela game as Vinotinto fans resident in Chile have flocked to every U-20 game.Another controversy stemmed from the case of Alejandro Marques, Barcelona’s 18-year-old hotshot who is conspicuous by his absence from the Vinotinto U-20. Venezuela’s efforts to field the striker have been frustrated by his father, who refuses to allow Marques to return to his nation of birth ostensibly due to the ongoing crisis and safety concerns. Coach Dudamel, however, has affirmed that Marques Sr. made a call-up impossible due to his unspecified “demands”: “Agreeing to them, and because of the youngest player, I would lose as a coach all moral authorities in front of my players,” he explained to reporters back in 2018.Such issues aside, the future undoubtedly looks bright for the Vinotinto. Dudamel’s last senior squad featured just seven players over the age of 25, and the team which takes on Argentina in March will most likely be bolstered by some of the stars of this U-20 generation, with perhaps Sosa and the commanding Makoun best positioned to break into the set-up in the immediate future.Dudamel’s prime goal, however, looking past this year’s Copa America, must be Qatar 2022. Venezuela remain the only CONMEBOL member never to have qualified for a World Cup, but hopes are higher than ever thanks to the glut of young talent coming through the ranks. “To get to the World Cup we need to keep improving our structures, we have to keep sending players to more competitive leagues,” Coronis explains.“When the World Cup expands we will obviously have more chance, but we have to maintain a constant line of development, if we keep working well we’ll have a great team to send to Qatar.” Bustamante similarly believes that the Vinotinto is still a work in progress: “We have an enormous talent that if channelled correctly will take us to our first World Cup very soon.“What is still missing is a cohesive element that allows the team to achieve consistency and identity in its playing style. The talent and will is there, but there are a lot more factors needed to achieve success.”Sooner or later, it is clear, Venezuela will be lining up alongside the world’s most powerful nations at a World Cup. And when the Vinotinto do make the top table we may well look back at their battling youngsters of 2017 and 2019 as the teams that took the first steps towards success, defying crisis and crippling economic hardships to establish themselves amongst the sport’s elite.
International Cricket Council CEO Dave Richardson on Monday said he doesn’t forsee any threat to the high-profile India-Pakistan World Cup match, insisting that the two teams are bound by an ICC agreement to show up.”For ICC events, all teams have signed a members’ participation agreement which requires them to participate in all the matches of the tournament and (in case of) any unjustified non-compliance with that provision, the playing conditions will kick in and the points will be awarded accordingly (to the other team),” he said when asked about the matter.There were demands that India should boycott the game against Pakistan in the World Cup in Manchester on June 16 in the wake of last month’s Pulwama terror attack which killed more than 40 CRPF personnel.Responding to the outrage, the Committee of Administrators (CoA) running Indian cricket also wrote a letter to the ICC urging it to boycott countries from where “terrorism emanates”, but did not specifically name Pakistan.Another controversy erupted when Indian team wore camouflage military caps during the third ODI against Australia in Ranchi as a mark of respect to the CRPF personnel who were killed in the Pulwama attack and donated its match fee to the National Defence Fund.Pakistan strongly objected to the gesture and and wrote to the world body, accusing India of politicising the game.The ICC, however, said the Indian team took prior permission from it and there was no political motive involved.”In this case, it was a one-off consent. It was granted subject to the message around the wearing of the caps simply being sympathy with the people, who had lost their lives in the (Pulwama) attack and in particular, to help them raise funds for the families of the people who had lost their lives,” Richardson said.advertisement”The ICC’s motto is clear we don’t want to mix politics with sports.”Asked about the ICC’s role in the resumption of bilateral ties between India and Pakistan, Richardson said it was completely up to the two cricketing boards.The ICC CEO said the perception about Pakistan among the rest of the world is slowly changing and the world body is supporting its member board to bring back international cricket to the nation.He also said that the successful hosting of Pakistan Super League (PSL) matches will do a world of good towards achieving the goal.Richardson also thanked foreign players, who made the trip to Pakistan for PSL.”Step-by-step, certainly Pakistan is on the right path,” he said, assuring ICC’s support to the PCB in its efforts to encourage foreign teams to visit Pakistan.Also Read | ICC rules out complacency on World Cup security after Christchurch mosque shootingsAlso Read | PCB pays USD 1.6 million to BCCI after losing case in ICC’s Dispute Resolution Committee
Peyton Manning was not a very good thrower of the football, and towards the end of his career, he was flat out bad. Hospitalized ducks were offended by some of Manning’s throws throughout his career, and yet he remained one of the best in the business for nearly 20 years. Why? Because he was better prepared, more accurate and three steps ahead of his competition.Oklahoma State quarterback Mason Rudolph has taken a page out of Manning’s metaphorical playbook, said Mike Gundy after Rudolph threw for 497 yards on 32 passes against Pittsburgh. While Rudolph doesn’t have the strongest arm in college football, he always knows where the ball is going and why it’s going there.That’s how you have a 51:7 TD to INT ratio over the last 23 games.“He prides himself on being the Peyton Manning, Tom Brady of college football,” said Gundy last Saturday. “That’s what he prides himself on, and he backs it up. Most people that are that committed that have some skill are going to be successful. His leadership and ability to be humble has been awesome.”“He’s a workaholic,” Gundy added this week. “The guy’s crazy. Over his footwork, his release, his study, the game plan. I meet with him on the night before games, usually Friday nights and he goes over the game plan. He knows it front and back. He understands down and distance. He understands hash marks. He understands blitz. He understands everything like a coach.”He’s got physical tools to boot. Rudolph has clearly improved his accuracy, and his arm strength has always been a plus. He possesses all the tools you could want a college senior to possess.“And he’s totally committed to being a student of the game,” said Gundy. “He wants to play this game for 20 more years and when you’re that committed to something in life, it’s extremely difficult to not have success.”Rudolph agreed with his head ball coach, noting that preparation for Saturdays is vital to whatever success he finds in his final year in Stillwater.“Peyton Manning has said so many times, ‘If you put the work in, you put the time in during the week, there’s no such thing as pressure,’” said Rudolph on Tuesday. “You do everything you can and go react to the defense. That’s the way I approach it. You control what you can control, and you’ll put yourself in a good spot.”There has been and will be much debate over the next year over whether Rudolph can be successful as a NFL quarterback. There are so many variables that go into that that it’s not even worth predicting.What I know is that he’s given himself a chance, and he’s turned himself into one of the all-time greats in Oklahoma State history by trying to become like the all-time greats of the sport. Is Mason Rudolph ever going to have the success Peyton Manning and Tom Brady have had in the NFL? The odds are heavily against it, but it won’t be for lack of preparedness.If you’re looking for the comments section, it has moved to our forum, The Chamber. You can go there to comment and holler about these articles, specifically in these threads. You can register for a free account right here and will need one to comment.If you’re wondering why we decided to do this, we wrote about that here. Thank you and cheers!
ShareEmailPrint To learn more, read: Posted on February 14, 2013March 21, 2017By: Sarah Blake, MHTF consultantClick to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to email this to a friend (Opens in new window)Click to print (Opens in new window)A Road Less Travelled, which is a partnership project led by Anglican Overseas Aid, Australia that supports nomadic pastoralists to improve maternal and child health within their communities in Ethiopia and Kenya, featured a blog post this week underscoring the challenges that go with efforts to fill the gap in health service coverage for women in Maasai communities in Kenya raising several questions about the role of traditional birth attendants within efforts to improve maternal health in these communities. From the blog post:The question now is: what can be done to bridge the gap? Could empowering the TBAs more help to bridge the gap, and contribute more towards safer deliveries? Should training be provided to TBAs to improve their skills? Should they be linked with the formal health system so that TBAs and professional health workers act collaboratively to assist women during pregnancy?To view the GMCH2013 video and PowerPoint presentation by James Senjura of the Mothers’ Union of the Anglican Church Kenya (MUACK), A Road Less Traveled’s partner in Kenya, click here.For additional information, visit A Road Less Traveled’s Blog here and their January guest post on this blog here.Share this:
ShareEmailPrint To learn more, read: Posted on May 22, 2014November 4, 2016By: Katie Millar, Technical Writer, Women and Health Initiative, Harvard T.H. Chan School of Public HealthClick to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to email this to a friend (Opens in new window)Click to print (Opens in new window)Caffeine can help us start our day or get us through a drowsy afternoon. But did you know caffeine can also help prevent a premature baby from having apneic spells, or periods of not breathing? Since 1977 we have known that pharmacological caffeine given to premature infants can help stimulate their immature brains and lungs to breath—preventing life threatening damage due to hypoxia, or lack of oxygen. This caffeine is usually given until the baby reaches 34 weeks gestation, or the time when the brains and lungs should be mature enough to breathe on their own.A recent study by Dr. Lawrence Rhein from Harvard Medical School and the Caffeine Pilot Study Group sought to evaluate if 34 weeks is really the best time to stop using caffeine. Dr. Rhein explained, “[34 weeks] is about that age that most babies stop having clinically obvious hypoxic spells. But the question has been, are there continued but less obvious episodes that we could and should be preventing? And can caffeine play a role in doing so?”What did the study find? Give the babies more caffeine. There are real, but less obvious, hypoxic spells after 34 weeks and giving caffeine to premature infants until 40 weeks, or term, gestation helps prevent them. The six week extension on administering caffeine prevented the hypoxic spells—or blood oxygen saturation levels below 90 percent. When blood oxygen levels were measured, babies in the extended caffeine treatment group experienced 52 percent less hypoxic spells and 47 percent less time under 90 percent oxygen saturation.Finding a healthy balance of oxygen levels for a premature infant is often a delicate science. While decreased oxygen can cause long term developmental morbidities and even death, supplemental oxygen and high oxygen saturation in the blood can also contribute to the development of retinopathy of prematurity (ROP), which may lead to blindness. The findings for this study provide at least a partial solution to this difficult balance by showing that caffeine can help stabilize oxygen saturation levels.Moving forward more research is needed to evaluate the types and consequences of the less obvious hypoxic spells occurring after 34 weeks. “Our data showed that [hypoxic] episodes can continue for weeks after caffeine is discontinued,” Rhein said. “Those episodes were not clinically obvious, but we don’t yet know which episodes we need to react to. We’re setting the stage to ask whether some of the episodes that we don’t think are significant can affect long-term cognitive development.” The answers to these questions have implications for both the future of the premature infant and family.If the hypoxic spells do affect long-term cognitive development, then treatment through extended caffeine has implications for improving outcomes and decreasing the need of special education services and health care costs to the family.Adapted from two articles—one in Vector, Boston Children’s Hospital’s science and clinical innovation blog and the other in news from Harvard Medical School.Do you have thoughts or insight on the effects of neonatal hypoxia? How your facility addresses neonatal hypoxia? Do you use caffeine? If not, why not? If you are interested in submitting a blog post on neonatal hypoxia, please email Katie Millar.Share this:
Posted on October 30, 2017October 30, 2017By: Jeffrey Smith, Vice President of Technical Leadership, JhpiegoClick to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to email this to a friend (Opens in new window)Click to print (Opens in new window)Long before I became a physician or heard the phrase “health systems,” I found myself in a situation where I had to understand and improve one.The importance of client-centered care in the context of health systems strengthening was an early and important global health lesson that I learned in the mid-1980s while volunteering abroad. I had just graduated from college and was contemplating medical school when I spent a year in the small village of Nepeña on the desert coast of Peru. In this village with no running water and limited resources, I saw firsthand why clients needed to be at the center of the health system conversation.Every week or so, a doctor would travel 40 kilometers from the nearest city, Chimbote, to our village clinic to see patients. People would walk out with prescriptions for basic medicines from the doctor, but they would never actually get those medicines: There was nowhere nearby to buy aspirin—much less penicillin or blood pressure pills. The prescriptions had no value.One evening in the plaza, I was talking to Rita, the woman who had helped to establish the village library. We began talking about what we could do to make medicines available to the people of Nepeña. She said, “We need a botiquín popular – a community dispensary.” With that, my volunteer project was launched. After consulting with the doctor to compile a list of important medicines, we built a locked cabinet, bought our first stock of medicines and established a plan for sustainable funding through clients’ purchases.Decades later, I’m even more convinced of the importance of putting people at the center of health systems, and particularly quality improvement initiatives.It is important to overcome the misperception that client-centered care is not a realistic goal in low-resource settings where there might be complicated structural and sociocultural barriers. In recent years, care has evolved from a traditional top-down model of care for clients to a more collaborative model of care with clients, and now toward a new model of care by clients—where clients are the drivers, and providers are the facilitators. Not surprisingly, clients assign greater value to care when they are direct participants. It’s all about perceived value.With that enhanced perspective on increasing women’s perception of the value of care, Jhpiego has begun implementing a group-based model of antenatal care (ANC) in response to the problems of low attendance and poor quality that plague traditional ANC. Globally, only 58% of women attend at least four ANC visits. For too many women, traditional ANC doesn’t provide enough return on their investment, so it’s a real opportunity cost for them. Group ANC, however, vastly increases that return on their investment. Women clearly see its value.In Nigeria and Kenya, where Jhpiego is leading a group-based ANC research study, pregnant women are active participants, providers and leaders throughout the care process. Upon arriving at the clinic for a group ANC session, the pregnant women take each others’ blood pressure, weigh each other and ask about the baby’s movements. This model reinforces the idea that each woman plays a critical role in the success of her own pregnancy – and in that of her fellow group members. A midwife or other clinical provider is still part of the model, offering one-on-one private appointments to each woman, but the clients are at the center of their own care.Preliminary results of this group ANC model indicate important improvements in the quality of care, the number of ANC visits and in the relationships between clients and their midwives. We hope this new model will result in increased retention throughout the ANC continuum, more facility-based deliveries and better outcomes for mothers and babies.Health system transformation happens when a pregnant woman—or any patient for that matter— believes that her health care is of great value, and is put at the center of care. That is where she has belonged all along.—Learn about the Maternal Health Task Force (MHTF)’s work to develop an adapted group ANC model for global implementation.Read more about group ANC on the MHTF blog.Share this: ShareEmailPrint To learn more, read:
Here are the details for this ACC matchup:Channel: ESPNSpread: Miami -2Over/Under: 43.5Announcers: Dave Flemming, Louis Riddick, Paul CarcaterraVirginia should give Miami all it can handle on Friday night. The team’s only loss this season came to Notre Dame on the road.Not only do the Cavaliers have a stingy defense that allows only 275.4 yards per game, they have a dual-threat quarterback in Bryce Perkins that has made a bunch of explosive plays this season.It’ll be interesting to see how Virginia plays coming off its bye week. At the very least, the defense should be ready to play against Miami’s backup quarterback. MIAMI, FL – APRIL 13: N’Kosi Perry #5 and Jarren Williams #15 of the Miami Hurricanes in action during the annual Spring Game at Nathaniel Traz-Powell Stadium on April 13, 2019 in Miami, Florida. (Photo by Mark Brown/Getty Images)We’re in for an excellent weekend of college football as there are several marquee matchups on the schedule. This week’s slate includes an important ACC showdown between Miami and Virginia.Miami is coming off a wild loss to Virginia Tech at home. Despite trailing 28-0 at one point during the game, the Hurricanes ended up one touchdown away from sending it into overtime.Jarren Williams suffered an upper body injury last weekend. Manny Diaz announced that N’Kosi Perry will be the starter for this week’s game.Perry played well against Virginia Tech in Week 6, throwing for 422 yards and four touchdowns. He’ll need another strong performance to lead Miami to a victory.
ARLINGTON, TX – DECEMBER 31: TV/radio personality Paul Finebaum of the SEC Network speaks on air before the Goodyear Cotton Bowl at AT&T Stadium on December 31, 2015 in Arlington, Texas. (Photo by Scott Halleran/Getty Images)Week 7 of the 2019 college football season started off with an upset, as No. 20 Virginia fell on the road to Miami, dropping its second game of the season.Will we get any more upsets today?ESPN college football analyst Paul Finebaum has one top team on “upset alert” heading into this afternoon.Finebaum doesn’t think No. 9 Notre Dame will lose at USC, though the Fighting Irish are in for a tough test. He has the Trojans taking it to Notre Dame tonight in a close game – but losing.Notre Dame vs. USC was consistently one of the better rivalry games in college football. However, with the Trojans struggling in recent years, the game has fallen off. The Irish enter the game as an 11-point favorite, but could be looking ahead to a contest against Michigan in two weeks. With an extra week to prepare for the Wolverines, Brian Kelly needs to have his team focused on the task at hand.Stay tuned for Saturday’s slate.
CLEMSON, SC – OCTOBER 07: Head coach Dabo Swinney of the Clemson Tigers walks the sidelines during the Tigers’ game against the Wake Forest Demon Deacons at Memorial Stadium on October 7, 2017 in Clemson, South Carolina. (Photo by Mike Comer/Getty Images)Clemson football head coach Dabo Swinney has revealed the punishment for the Tigers player who threw a punch during Saturday’s blowout win over Louisville.Tigers cornerback Andrew Booth Jr. was ejected from Saturday’s win when he threw a punch in the third quarter. Booth hit Louisville’s Trenell Troutman when he was on the ground after the two players went at it during a punt return.Swinney has revealed that Booth had to take the bus home with the team’s managers, instead of flying back with his teammates. The bus trip home was about 450 miles.“He rode back on our manager bus. That’s where it started,” Swinney told ESPN. “The rest of it will be handled in-house.” Swinney added that the rest of the punishment will be handled in house.The freshman cornerback has reportedly apologized for his actions.“[He] has responded well,” Swinney said. “He is disappointed in himself, embarrassed. He has apologized to our team and our AD. He’s been extremely remorseful. What happened is way out of character for who he is. Very pleased with how he has taken ownership. He had a long bus ride home last night and plenty of time to think about it.”Clemson (7-0) is set to host Boston College on Saturday night.
Frank Lampard has been urged to take lessons from Jugen Klopp’s “heavy metal football tactics” at Liverpool as Chelsea wait on their first competitive win under a new boss.The Blues have taken in three games so far in 2019-20, coming unstuck in two of them.An opening day 4-0 reversal against Manchester United in the Premier League was followed by a UEFA Super Cup penalty shootout defeat to Liverpool. Article continues below Editors’ Picks What is Manchester United’s ownership situation and how would Kevin Glazer’s sale of shares affect the club? Ox-rated! Dream night in Genk for Liverpool ace after injury nightmare Messi a man for all Champions League seasons – but will this really be Barcelona’s? Are Chelsea this season’s Ajax? Super-subs Batshuayi & Pulisic show Blues can dare to dream A first point of the campaign was collected on home soil against Leicester, but the Stamford Bridge faithful had been hoping for more than a 1-1 draw with the Foxes.Lampard’s regime is still very much a work in progress, with former Blues star Pat Nevin aware that a new system and mindset will require careful management – similar to that adopted at Anfield.He told Chelsea’s official website: “Playing the high tempo game Frank wants and that we are already enjoying is not easy.“It is interesting to see that Jurgen Klopp adapts his heavy metal football tactics when he thinks his players need a little break.“This dilemma of weariness v work rate may not be a concern for a few weeks now, but it will return when the Champions League group stage starts.“Playing on a Tuesday or Wednesday and then returning to face a rested side at the weekend is something that has to be managed.“When too many players are tired the game opens up, the play gets stretched and because of that James Maddison in particular got acres of space in the number 10 position on Sunday, something that should never be allowed.”Lampard is looking to put his own stamp on things in west London, but getting his message across is going to take time and players are still working on building up full match sharpness.Nevin added: “The system itself was bold once more, with [N’Golo] Kante pushing forward from the right of the midfield and Mason Mount playing left midfield but attacking as often as possible.It was the Frank Lampard position of doing a box-to-box shift but most interested in the opposition box.“The same players could easily shift from a 4-3-3, to a 4-2-3-1, to a diamond in midfield.“The biggest problem wasn’t tactical in the end, it was the fact that we had to make some changes after the hour, but to be honest there were just too many tired players out there.“[Olivier] Giroud, Jorginho and [Christian] Pulisic were subbed but I would not have batted an eyelid if it had been Mason, or even N’Golo or Pedro. The latter two both had injuries to contend with to add to the tiredness.“That is the game at the top level, and it is all about finding answers to these sometimes seemingly intractable problems.”Nevin went on to say, with Chelsea next in action against Norwich on Saturday: “It is disappointing to have only one point after two games, so we are now desperate for a win in the next one.“A start of one or two points out of nine would be the last thing Frank wanted. Fortunately there is a willingness to understand the difficulties and there is unlikely to be any real pressure coming from the stands in the short term, which really helps the players. In tough times having the Chelsea fans onside makes a huge difference.” Check out Goal’s Premier League 2019-20 fantasy football podcast for game tips, debate and rivalries.
Consider this a statement from Liverpool.On a weekend where Manchester City scored eight, the Reds recorded what could, in the grand scheme of things, be just as significant a victory. Their 2-1 win over Chelsea at Stamford Bridge restores their five-point cushion at the top of the Premier League. That’s seven successive away league wins for Jurgen Klopp’s side – a new club record. They’ve won their last 15, home and away, and are on their best unbeaten run, 23 games, since 1990. Article continues below Editors’ Picks Ox-rated! Dream night in Genk for Liverpool ace after injury nightmare Messi a man for all Champions League seasons – but will this really be Barcelona’s? Are Chelsea this season’s Ajax? Super-subs Batshuayi & Pulisic show Blues can dare to dream Time for another transfer? Giroud’s Chelsea spell set to end like his Arsenal career We know what happened that year, of course, and the desire to end that torturous wait for a league championship burns as fiercely as it ever has. Results like this, though, only reinforce the idea that perhaps, just perhaps, this really will be Liverpool’s year.Chelsea, traditionally, is a place where they struggle. Only at Old Trafford have they lost more Premier League games down the years, and Klopp had been surprised to learn at his press conference on Friday that his team had won only one of their last 12 away games against their top-six rivals.But if the question was could they handle Frank Lampard’s young, vibrant outfit, then they answered in the affirmative – just.We are used to his team tearing opponents apart through speed and stealth, cutting them open with incisive, thrilling combination play.Here, they reached into their bag and pulled out a different weapon entirely. They got their set-pieces out.“Scoring more goals is something I’d like to improve,” Trent Alexander-Arnold had said, in an interview published on Sunday morning. Maybe the full-back had had a premonition, because it took him just 14 minutes here to make good on his word. It looked a well-rehearsed routine. After Sadio Mane was fouled, just outside the Chelsea penalty area, Alexander-Arnold, Mohamed Salah and Jordan Henderson stood together over the ball. They talked, they plotted. Then, they executed.As Henderson primed himself for the strike, Salah rolled his foot over the ball and sent it behind him for Alexander-Arnold, who unleashed a rocket into Kepa Arrizabalaga’s top left-hand corner. It was the youngster’s first goal since last November, a direct free-kick at Watford. He doesn’t do tap-ins.Liverpool’s second goal was equally well thought-out, Alexander-Arnold rolling the ball to Andy Robertson and the Scot crossing for the unmarked Roberto Firmino to head home from close range, as Chelsea’s zonal marking system malfunctioned badly. The trend continues. Since the start of last season, Liverpool have scored 34 goals from set-piece situations, which is at least seven more than any other team. They really have developed into the complete football team. They look like they have all the tools. They wobbled a bit here, mind. They were knocked out of their stride by Chelsea’s second-half energy and vibrance, and indebted to a late miss from Mason Mount which would have salvaged a point for the home team. They defended desperately at times, impressively at others. Beaten in Naples in midweek, there were signs of fatigue as this game wore on.In terms of fluency and quality, they can play a lot better. In terms of results, though, they can’t.That’s six wins from six now, 18 points when nobody else has managed more than 13. It’s only September, but with every victory they are laying down a marker. They’ve now lost just two of their last 52 league matches; remarkable consistency. To win the Premier League against City requires near perfection, and Liverpool are there at the moment.No wonder Klopp was smiling at the final whistle. He knew, as everyone knew, what a big win this was.The Red machine rolls on. Subscribe to Goal’s Liverpool Correspondent Neil Jones’ weekly email bringing you the best Liverpool FC writing from around the web
Ole Gunnar Solskjaer may need as many as 10 transfer windows to make Manchester United competitive again, says Mark Robins.The man calling the shots at Old Trafford has seen out two transfer markets in his reign so far.No additions were made in the first, as he was interim coach at the time, while only Harry Maguire, Aaron Wan-Bissaka and Daniel James were added to the Red Devils’ ranks over the summer. Article continues below Editors’ Picks Ox-rated! Dream night in Genk for Liverpool ace after injury nightmare Messi a man for all Champions League seasons – but will this really be Barcelona’s? Are Chelsea this season’s Ajax? Super-subs Batshuayi & Pulisic show Blues can dare to dream Time for another transfer? Giroud’s Chelsea spell set to end like his Arsenal career With the departures of several experienced stars taken into account, United are considered by some to be no stronger than they were at the end of 2018-19.Many have suggested they are in fact weaker this term, with Solskjaer paying the price as he falls under ever-increasing pressure amid ongoing struggles for consistency.Former United striker Robins, who once saved Sir Alex Ferguson from the sack, fears it is going to take several more years and considerable patience for those in Manchester to get back on track.He told talkSPORT: “I’d love to see Ole get the time to be able to build, because he is not doing it in one window; he’s going to need six, seven, eight, nine… 10 windows!”You don’t get that time generally. Ultimately what he is doing is trying to implement the processes Sir Alex had in place prior to his retirement.“I think that is a huge ask. Remember Sir Alex went years prior to winning his first trophy and that will be very, very difficult to replicate because of the modern-day pressures.”Having said that, if things are moving in the right direction then he will get some time. I also think Ole is a character that’s not putting himself front and centre; he’s putting his club front and centre.”So he will be part of a process moving forward to make United successful again, and I don’t think he makes any qualms about that. I think that is something to be applauded and respected.”It remains to be seen whether Solskjaer will be given the time he requires in order to complete a sizeable rebuilding job.Things are not about to get any easier for the Norwegian as United return to action after the international break with a home date against Premier League leaders Liverpool. Check out Goal’s Premier League 2019-20 fantasy football podcast for game tips, debate and rivalries.
GUILFORD, CT – February 6, 2017 – American Cruise Lines announced that it will be a national sponsor of PBS’ most-watched ongoing series ANTIQUES ROADSHOW beginning today, February 6th. Now entering its 21st season, 14-time Emmy® Award nominated ANTIQUES ROADSHOW features antiques owners from across the country bringing in items to be appraised by the country’s leading antiques and collectibles experts. Each antique not only has value, but is intrinsically tied to our history. These are the stories that make the series special and what sparked the relationship with American Cruise Lines. “We are excited to embark on this relationship with PBS and ANTIQUES ROADSHOW,” says Timothy Beebe, Vice President of American Cruise Lines. “The 8.5 million weekly viewers of ANTIQUES ROADSHOW and guests of American Cruise Lines have a common bond. They share a passion for American history and culture, which ultimately makes this sponsorship a perfect fit.” “I am thrilled that American Cruise Lines has joined us as a sponsor of ANTIQUES ROADSHOW,” says Executive Producer Marsha Bemko. “The support of our sponsors helps make it possible to continue our search for America’s hidden treasures. We’re excited to share the adventure as we explore history throughout our country!” American Cruise Lines offers over 35 itineraries ranging from 4 to 21 nights in length including the Pacific Northwest, Alaska, New England, the Southeast and the entire Mississippi River system. American Cruise Lines also offers a number of theme cruises that highlight the rich history of the United States, including Mark Twain, Civil War, and Lewis & Clark cruises. American Cruise Lines aims to provide a comprehensive cruise experience with the help of onboard experts, guided shore excursions, and vibrant ports of call. Through this relationship with ANTIQUES ROADSHOW, American Cruise Lines will continue to honor its commitment to education and enrichment. About American Cruise LinesAmerican Cruise Lines is the leading US cruise line, with the largest fleet of US ships. It offers more than 35 itineraries, ranging from 4 to 21 nights in length including the Pacific Northwest, Alaska, New England, the Southeast and the entire Mississippi River system. The line has been continuously recognized for its new ships and for providing superb service to guests and travel agents before, during, and after a cruise. To learn more about American Cruise Lines, visit http://americancruiselines.com/home or call 800-814-6880. Find us on Facebook at https://www.facebook.com/americancruiselines or follow us on Twitter at https://twitter.com/American_Cruise.