Reader Caroline Robinson snapped this picture of a car that got stuck in a patch of wet cement Thursday afternoon on 69th Street between Tomahawk and Belinder. WaterOne workers had been installing a new water main in the area, and had finished pouring cement to close up the hole in the road when the black sedan drove by and immediately sunk.A tow truck arrive to pull the vehicle out of the hole, and the motorist was able to drive away with the vehicle apparently unharmed.
LinkedIn “We usually think of traits in terms of a whole person, or animal. We’re finding that when we look at the level of cells, genetics is much more complicated than we thought,” says Christopher Gregg, Ph.D., assistant professor of neurobiology and anatomy and senior author of the study which publishes online in Neuron on Feb. 23. “This new picture may help us understand brain disorders,” he continues.Among genes regulated in this unorthodox way are risk factors for mental illness. In humans, a gene called DEAF1, implicated in autism and intellectual disability, shows preferential expression of one gene copy in multiple regions of the brain. A more comprehensive survey in primates, which acts as a proxy for humans, indicates the same is true for many other genes including some linked to Huntington’s Disease, schizophrenia, attention deficit disorder, and bipoloar disorder.What the genetic imbalance could mean for our health remains to be determined, but preliminary results suggest that it could shape vulnerabilities to disease, explains Gregg. Normally, having two copies of a gene acts as a protective buffer in case one is defective. Activating a gene copy that is mutated and silencing the healthy copy – even temporarily – could be disruptive enough to cause trouble in specific cells.Supporting the idea, Gregg’s lab found that some brain cells in transgenic mice preferentially activate mutated gene copies over healthy ones. “It has generally been assumed that there is correlation between both copies of a gene,” says Elliott Ferris, a computer scientist who co-led the study with graduate student Wei-Chao Huang. Instead, they found something unexpected. “We developed novel methods for mining big data, and discovered something new,” Huang explains.The investigators screened thousands of genes in their study, quantifying the relative levels of activation for each maternal and paternal gene copy and discovered that expression of the two is different for many genes. Surprised by what they saw, they developed statistical methods to rigorously test their validity and determined that they were not due to technical artifacts, nor genetic noise. Following up on their findings, they examined a subset of genes more closely, directly visualized imbalances between gene copies at the cellular level in the mouse and human brain.Results from Gregg and colleagues build on previous research, expanding on scenarios in which genes play favorites. Imprinted genes and X-linked genes are specific gene categories that differentially activate their maternal and paternal gene copies. Studies in cultured cells had also determined that some genes vary which copy they express. The results from this study, however, suggests that silencing one gene copy may be a way in which cells fine tune their genetic program at specific times during the lifecycle of the animal, or in discrete places.“Our new findings reveal a new landscape of diverse effects that shape the expression of maternal and paternal gene copies in the brain according to age, brain region, and tissue type,” explains Gregg. “The implication is a new view of genetics, one that starts up close.” Share on Facebook Email Share on Twitter Share Most kids say they love their mom and dad equally, but there are times when even the best prefers one parent over the other. The same can be said for how the body’s cells treat our DNA instructions. It has long been thought that each copy – one inherited from mom and one from dad – is treated the same. A new study from scientists at the University of Utah School of Medicine shows that it is not uncommon for cells in the brain to preferentially activate one copy over the other. The finding breaks basic tenants of classic genetics and suggests new ways in which genetic mutations might cause brain disorders.In at least one region of the newborn mouse brain, the new research shows, inequality seems to be the norm. About 85 percent of genes in the dorsal raphe nucleus, known for secreting the mood-controlling chemical serotonin, differentially activate their maternal and paternal gene copies. Ten days later in the juvenile brain, the landscape shifts, with both copies being activated equally for all but 10 percent of genes.More than an oddity of the brain, the disparity also takes place at other sites in the body, including liver and muscle. It also occurs in humans. Pinterest
Share Delroy Williams copped two prizes in this year’s competitions (file photo)The Division of Culture has announced the winners of the Independence 2014 Literary Competitions. The announcements were made at the Cultural Gala on November 3. The competitions were in English Poetry, Short Stories and Kweyol Poetry. Leandra Lander topped the English poetry category with her poem ‘I Love Her Still’. Ian Jackson copped second prize with his poem ‘Bosum Buddy’ while Delroy Williams earned the third prize with his poem “A Woman of Roseau”.In the Short Story category, Michelle Belle captured the first prize with a story entitled “Neg Mawon”.Delroy Williams won the second prize with ‘The Bond” while Judith Margaret Alexis copped the third prize with “Carnival Nightmare”.In the Kweyol Poetry category, the first prize went to Justina Prince John with a poem entitled “Domnik Bat Ladje”. Leandra Lander copped the second prize with the poem “I Pa Ni Dot Kon Gwan manman mwen” while Iris Andre won the third prize with the poem “Konet Kont Nati Lil la”. Share Share Sharing is caring! 304 Views no discussions Tweet LocalNews Independence 2014 Literary Competition winners announced by: – November 6, 2014
Upd. at 19:44 Sport EN Cesc Fabregas spoke openly, honestly and refreshingly with ‘Al Primer Toque’ on Thursday night. He spoke about his time at Barcelona, his summer move to Chelsea and Lionel Messi’s happiness at the Catalan club. Here are the best parts of his interview. CET On national team rifts: “In the end, we all wanted to win. It had been tough after some of the matches between Madrid and Barça. When you have to be teammates with people that usually are your rivals it is difficult, but we managed it OK. Now there is a really good group with the national team. Everything is fine with Ramos and me now. We’ve been teammates since we were 16 and we’ve always got on well. We spoke. Everything is good.” On Messi staying put: “Messi is happy at Barça and Barça are happy with him. I feel bad that they say I could mediate the arrival of Messi at Chelsea. Who am I to talk of contracts? I am just a player. He’ll do what makes him most happy. As his friend, colleague and a footballer, if I had the opportunity to play with Leo again, I would welcome it. I don’t know Luis Enrique. I know Leo and I doubt that he is thinking of what they are saying because he’s an easy-going guy and I have never seen anything like that in the three years we played together.” On linking up with Jose: “A few months ago I could never have imagined myself at Chelsea, especially because of my past with Arsenal, but that’s football. When I decided to leave Barcelona I looked for the best option for me, thinking of myself. I spoke with Mourinho and in 10 minutes I’d made my decision. He convinced me. It was the week after the final game of la Liga, I called Bartomeu and Zubi and within three days it was done.” Positional problems: “Xavi’s position is the one I like the most. At Arsenal I played as an attacking midfielder, but the manager gave me a lot of freedom there. At Barça I started there, until they started to move me about. That was difficult because I was used to having more freedom on the pitch.” On the Ballon d’Or: “All three could win it. The best in the world, the most talented is Messi. They say he’s had his worst year but he’s only scored three less goals than Cristiano, who was at his best. Tactically and in football terms, Messi is better. Messi participates more. For me, in my team, I would always prefer Leo.” 09/01/2015 Tough at Camp Nou: “Barça is the most difficult place to play for a footballer. It is the biggest challenge. It is not enough just to win, it is about how you win as well.”
Sport EN Bakkali, who had also been linked with a move to the Premier League, explained his delight at joining Valencia. Valencia have confirmed the signing of Belgian international Zakaria Bakkali from PSV Eindohoven. CEST Bakkali will now travel to Austria, where he will join up with his new teammates for a pre-season training camp. “I arrive here fully motivated to work hard and to help my new teammates. I had decided a while ago that I wanted to continue my career away from Eindhoven and I had many options from which to choose. Coming to Valencia CF and La Liga is a dream come true for me.” “Valencia Club de Futbol have today reached an agreement with Belgian international Zakaria Bakkali to join the club through to June 30th, 2020,” they wrote. “I am very young and it is a big step for me to join a club with the tradition and qualities of Valencia CF, in such an attractive and competitive league,” he said. Los Che released a statement on Monday revealing the deal, which had long been in the works, has now been completed. Upd. at 17:08 “The young Belgian player, born on January 20th, 1996, arrives on a free transfer after the conclusion of his contract at PSV Eindhoven.” 06/07/2015
By JESSE GRAHAM EMERALD Police are searching for two males who caused $2000 worth of damage near the wake for…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
Premier DANIEL ANDREWS released a statement to the media on Sunday 17 May, advising cafes, restaurants and pubs will be…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
Mitch Crisanti scored four times, twice during a five-goal first-period explosion, to spark the Vancouver Northwest Giants to an 8-3 decision over Kootenay Ice in B.C. Major Midget Hockey League action Sunday in Burnaby.The win completed a weekend sweep for the Giants over the Kootenay squad. Vancouver won the opener Saturday 4-0.Vancouver jumped all over the Ice to open the game, chasing Kootenay starter Brett Soles of Cranbrook from the net after scoring five on the n netminder.Jake Lucchini of Trail stopped a bit of the bleeding with a late first period goal for Kootenay.In the second, with back up Kimberley Newell now in goal for Kootenay, the hosts continued to pour it on the Ice as Crisanti scored two more times in the period along with Cole Todd to increase the advantage to 8-2.Will Lightfoot of Cranbrook scored in the second for Kootenay.In the third the Ice notched the final goal of the game as Nelson’s Brandon Sookro scored.Saturday, four different players scored for the Giants as Vancouver shutout the road-weary Ice.The Ice falls to 1-12-1 while the Giants climbed to within two points of league-leading Cariboo Cougars of Prince George.Kootenay returns to action Saturday when the clubs hosts the Fraser Valley Bruins in a pair of games at the Castlegar and District Community Complex.Game time Saturday is 7 p.m. Sunday puck drops at 9:30 a.m.Fraser Valley is tied for ninth in the 11-team league, seven points up on Kootenay.ICE NOTES: Jake Lucchini continues to lead the Ice in scoring with 15 points along with eight goals. Brandon Sookro has scored five times while Castlegar’s Darren Mederios has 10 [email protected]
Pat Lam’s received a twin boost ahead of Connacht’s final Challenge Cup pool game with Enisei.Robbie Henshaw and Kieran Marmion are both in contention to play at the Sportsground having recovered from injury.Both players are also likely to feature in Joe Schmidt’s squad for the Six Nations when it’s revealed later.Staying with Connacht, Hooker Jason Harris-Wright suffered a concussion during the first half of the game with Brive on Saturday. The 27-year-old will continue to go through the return-to-play protocols.Back row forward Eoin McKeon returned form elbow injury to start in the B&I cup game for the Connacht Eagles at the weekend. However, the Galway man sustained a hip pointer injury and is subsequently unavailable for selection this weekend.Versatile back Darragh Leader, also returned to match action at the weekend when he lined out for the Eagles but re-aggravated a previous wrist injury during the game. The 22-year-old from Galway remains unavailable for selection as he consults a surgeon this week.Craig Ronaldson remains unavailable as pain continues on a shoulder impingementThe Connacht team to face Enisei-STM will be named on Friday at 12 noon.print WhatsApp Facebook Twitter Email
Other sponsors that sponsored our tournament are :Celtic School of Motoring, Noel Reilly Crash Repairs, Dolan’s Bar, Dr. Sandra Lewis, Chiropractor, The Big Bite and Star Trophy Centre Ballymoe.Williamstown Handball Club would like to thanks all the participants who came from near and far to compete in our annual tournament. We thank our sponsors sincerely as without their support we would not be able to host our tournament. We are indebted to the many parents and juvenile members of our club who helped out in so many ways over the weekend, by making tea and refreshments, by refereeing, by running between courts and tidying up each evening. We would also like to thank our sister club, Williamstown GAA Club, for the use of the Complex, without which, we would not be able to host our tournament. So until next yearGo n-éirí an bóthar leat and keep playing handball!!print WhatsApp Facebook Twitter Email In the Hubert Deane and Associates Ltd. Ladies Open final, Roscommon’s Fiona Tully took on Claregalway’s up and coming star Niamh Heffernan in a terrific final. Having beaten 2014 Ladies ‘B’ Champion Sinéad Ní Ainle, in the semi – final, Niamh was in high spirits going into this match. However, as always with Fiona, she can produce fantastic handball in the blink of an eye, and unfortunately for Niamh, this is exactly what happened. Fiona took the first game 15/9 after some outstanding handball from both girls. Niamh looked sharp and used her agility on the court to help keep in touch with the dominant Tully. This unfortunately was not enough and Fiona eased through the second game taking the Hubert Deane Ladies Open Title for 2016. The future is bright for these to players and I have no doubt that they will meet again in many tournaments in the coming years.Here is a list of all the results:Glenamaddy Credit Union U11 Boys: Winner Fiachra Ó’Duill, R-Up: Irslam YakhyaevBurke Motors Williamstown U11 Girls: Winner: R-Up:David Burke Electrical U12Boys: Winner: Kyle Jordan, R-Up: Cormac FinnSparkey’s Discount Store U12 Girls: Winner: Skylynn O’Malley Walsh, R-Up: Carragh KennedyMichael Whyte Engineering U14 Boys: Winner: Cormac Scollan, R-Up: Mikey KellyWispy’s Discount Store U14 Girls: Winner: Heather Burke, R-Up: Cailliosa Ní DhúillAPK Architects and Engineers U16 Boys: Winner: Gareth Delaney, R-Up Fionn CusackTarmeys Tavern U18Boys: Winner: James Prentice, R-Up: Diarmuid MulkerrinsDG Roofing and Cladding Ladies ‘B’: Winner: Ellen O’Connor, R-Up: Shonagh RuaneKennedy’s Bar Combined Masters: Winner: Brian Havern R-Up: Frank MackenHubert Deane and Associates Ladies Open: Winner: Fiona Tully, R-Up Naimh Heffernan.E.M.P. FURNITURE LTD Men’s Open: Winner: Martin Mulkerrins, R-Up: David Hope Hope fades as Mulkerrins conquers David.In the E.M.P. Furniture Ltd Men’s Open final, Martin Mulkerrins faced off against Offaly’s David Hope. With Mulkerrins’ reputation going before him, many thought this was a foregone conclusion but as his name suggests, David was hopeful he could pull off a surprise. In the first game Martin raced into an 8/0 lead and at this point the crowd began to think it was all over. However David came back into the tie steadily and closed the gap in the first game to 9/7. It was side in side out with martin picking off a few vital aces in between times and he eventually took the first game convincingly enough 15/7. The second game started like the first and Martin again picked off scores for fun, using his power and accuracy to lay down a 6/0 lead. David did not give up and fought back to go one up at 7/6 and again at 11/10. David’s serve was causing Martin some problems and the Offaly man was showing he could fly kill as good as the rest of them. When push came to shove, David held his nerve and closed out the second game 15/14 to cause a tiebreak. Martin was not going to be denied his maiden Williamstown One Wall Open Title and he wasted little time in the tiebreak to use his fitness to full advantage as he pushed David from side to side before sealing victory on an 11/2 score line.Tully rises to the top of the pile. In the Ladies ‘B’ final Ellen O’Connor, a long time supporter of the tournament captured the Ladies ‘B’ title which will see her play the senior grade next year. In the final she beat Mayo’s up and coming Shonagh Ruane to claim the title. Again in the Girl’s U14 grade, the talent on show was at a very high level and when the final came around Armagh’s Callíosa Ní Dhúill went head to head against Mayo’s Heather Burke. In a tense affair and with some great shots and gets by both girls, Burke just snatched it at the death and claimed the championship for 2016. Williamstown Handball Club hosted a memorable One Wall Tournament again this year with many old faces returning and some new ones coming along to experience the club’s hospitality. Play got under way at 7pm on Friday night with juveniles filling all three courts until 10pm when the various grades were whittled down to the last rounds. Saturday saw a mixture of sunshine and showers weather wise, but on the court some of the country’s best handballing talent was to be seen in the juvenile brackets. The skills on show were breathtaking with names like Finn, Yakhyaev, Ó’Dúill, Scollan, Kelly and many more on the lips of both coaches and parents alike. The U16 Boy’s grade saw some of the best talent on show at the weekend and the shear fitness and athleticism was a sight to behold with tiresome rallies and heartbreaking gets all key features of the grade. In the finish there could only be one winner and that accolade went to St. Coman’s Gareth Delaney for 2016. The Boy’s U18 grade saw two future stars of the game reach the final but not before being put to the pin of their collars by the many competitors in this grade. In the final James Prentice from the Ballina Club in Co. Tipperary had just too much for Moycullen’s Diarmuid Mulkerrins and captured the title 15/14, 6/15, 11/7.