Top 100 firms double in value to $16.2 trillion: Apple heads list as HSBC named UK’s most valuable company

first_img whatsapp Top 100 firms double in value to $16.2 trillion: Apple heads list as HSBC named UK’s most valuable company Show Comments ▼ The world’s biggest 100 firms now have a combined value of more than $16 trillion (£10.7 trillion), almost double their market capitalisation in 2009, a PwC study reveals today.Technology firms have driven the boom in valuations – just 12 firms in the sector have a combined valuation of $2.8 trillion. Six years ago, the 11 firms then in the top 100 were worth just under $1 trillion.The most valuable firm in the world is Apple at $725bn – it overtook Exxon Mobil in 2012 and has cemented its rank since.Businesses now need to be worth a minimum of $85bn to enter the top 100 – more than twice the $40bn in 2009, and up from $81bn a year ago.By country, the US has the most firms in the top 100, at 53, up from 47 in 2014.China has taken the second spot from the UK, with 11, while Britain has eight in the league table.The most valuable new entrant is Alibaba, the Chinese e-tailing giant which went public last year. It is placed at number 22 on the list, with a valuation of $205bn.The most valuable British firm is HSBC, at $164bn. It came in at number 36 in the league table.“The US has increased its domination of the ranking – seven of the top 10 and 13 of the top 20 are American,” said PwC’s Clifford Tompsett.“Looking at these companies, the likes of Apple, Google, Microsoft, Berkshire Hathaway and Facebook, it is apparent their success has been driven by innovation and their global reach.”“US corporates have also more aggressively used their scale and relatively higher valuations to increase their growth through strategic acquisitions.” whatsapp Monday 1 June 2015 8:44 pmcenter_img Express KCS by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMaternity WeekA Letter From The Devil Written By A Possessed Nun In 1676 Has Been TranslatedMaternity WeekPost FunKate & Meghan Are Very Different Mothers, These Photos Prove ItPost FunInvestment GuruRemember Cote De Pablo? Take A Deep Breath Before You See Her NowInvestment GuruEquity MirrorThey Drained Niagara Falls — They Weren’t Prepared For This Sickening DiscoveryEquity MirrorTele Health DaveRemember Pierce Brosnan’s Wife? Take A Deep Breath Before You See What She Looks Like NowTele Health DaveTaonga: The Island FarmThe Most Relaxing Farm Game of 2021. No InstallTaonga: The Island FarmLivestlyThe Best Redhead Actresses, RankedLivestlyTotal PastThis Was Found Hiding In An Oil Painting – Take A Closer LookTotal PastAtlantic MirrorA Kilimanjaro Discovery Has Proved This About The BibleAtlantic Mirror Read This NextRicky Schroder Calls Foo Fighters’ Dave Grohl ‘Ignorant Punk’ forThe Wrap’Drake & Josh’ Star Drake Bell Arrested in Ohio on Attempted ChildThe WrapCNN’s Brian Stelter Draws Criticism for Asking Jen Psaki: ‘What Does theThe Wrap’Kevin Can F**k Himself’ TV Review: Annie Murphy Blows Up the Idea of aThe WrapDid Donald Trump Wear His Pants Backwards? Kriss Kross Memes Have AlreadyThe WrapHarvey Weinstein to Be Extradited to California to Face Sexual AssaultThe WrapPink Floyd’s Roger Waters Denies Zuckerberg’s Request to Use Song in Ad:The Wrap’Black Widow’ First Reactions: ‘This Is Like the MCU’s Bond Movie’The WrapKatt Williams Explains Why He Believes There ‘Is No Cancel Culture’ inThe Wrap Share Tags: Alibaba Apple Company HSBC Holdingslast_img read more

Eurozone economy posts sluggish expansion in September as concerns grow over Spain

first_img Chris PapadopoullosChris Papadopoullos was City A.M.’s economics reporter until February 2016. He is an economist at OMFIF. More From Our Partners Native American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgFans call out hypocrisy as Tebow returns to NFL while Kaepernick is still outthegrio.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgLA news reporter doesn’t seem to recognize actor Mark Currythegrio.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgMan on bail for murder arrested after pet tiger escapes Houston homethegrio.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgColin Kaepernick to publish book on abolishing the policethegrio.comRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.com whatsapp Show Comments ▼ Monday 5 October 2015 9:25 am by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMoneyPailShe Was A Star, Now She Works In ScottsdaleMoneyPailSwift VerdictChrissy Metz, 39, Shows Off Massive Weight Loss In Fierce New PhotoSwift VerdictPost FunKate & Meghan Are Very Different Mothers, These Photos Prove ItPost FunComedyAbandoned Submarines Floating Around the WorldComedyMaternity WeekA Letter From The Devil Written By A Possessed Nun In 1676 Has Been TranslatedMaternity Weekzenherald.comMeghan Markle Changed This Major Detail On Archies Birth Certificatezenherald.comGameday NewsNBA Wife Turns Heads Wherever She GoesGameday NewsBridesBlushThis Is Why The Royal Family Kept Quiet About Prince Harry’s Sister BridesBlushEquity MirrorThey Drained Niagara Falls — They Weren’t Prepared For This Sickening DiscoveryEquity Mirror The Eurozone economy managed to keep up its lacklustre economic recovery in September, new survey figures show this morning.Markit’s economy-wide purchasing managers’ index (PMI) – derived from surveys of businesses – slipped to a score of of 53.6 in September from 53.4 in August. Despite the dip, the PMI is above the 50 level which implies business activity expanded over the month. Markit said it remained consistent with economic growth of 0.4 per cent in the three months to September, which is the same rate of growth as the previous three months.Yet any further signs of a slowdown would tempt European policy makers to beef up stimulus measures, such as the European Central Bank’s (ECB) €1.1 trillion (£810bn) asset purchase programme, which officials have been quick to say will happen should the economy weaken.“The failure of the economy to pick up speed over the summer will be a disappointment to the ECB, especially with job creation sliding to an eight-month low,” said Markit chief economist Chris Williamson.“The weakening of the pace of expansion in September raises the risk of growth fading further in the fourth quarter, which would in turn boost the likelihood of the ECB opening the QE taps further.”Concerns were also raised over Spain’s growth after its economy-wide PMI dropped to a score of 55.1 from 59.6, signalling the country’s slowest growth so far in 2015.Spain has grown around twice as fast as the Eurozone average this year, but is yet to reach pre-recession levels of output.“The rest of the year will be crucial in determining whether the Spanish economy continues to improve or eases back towards stagnation,” said Andrew Harker, senior economist at Markit. whatsapp Eurozone economy posts sluggish expansion in September as concerns grow over Spain Sharelast_img read more

TSX rallies as oil prices and loonie stabilize

first_imgThe S&P/TSX composite index advanced 207.35 points or 1.38% to 15,241.88 on Monday, with materials and gold stocks leading the way.In New York, the Dow Jones industrial average soared 410.37 points or 1.70% to 24,601.27. The S&P 500 index was up 36.45 points or 1.39% to 2,656.00, and the Nasdaq composite index was up 107.47 points or 1.56% to 6,981.96.“The strength today is a continuation of the rebound we saw midday last Friday. I would still categorize this as a little bit more of a reflex to the extreme selling we saw last week, and I say that because the underlying data has remained categorically positive,” said Craig Fehr, a Canadian markets strategist at Edward Jones in St. Louis.“I would say more broadly the economic data around the world suggests that growth is on the upswing and corporate earnings data continues to come in quite strong. And I’d say those were trends that never really saw disruption, even though we saw major disruption in the performance of global stock markets last week.”Among some of the big earners Monday was Restaurant Brands International Inc. The owner of Burger King and Tim Hortons moved up $4.39, or 6.18%, to $75.48 after outperforming analyst expectations on its fourth quarter profit.Meanwhile, Shopify Inc. jumped $10.67, or 7.10%, to $161.05 amid news the Ontario government has inked a deal to use its e-commerce platform for cannabis sales online and in stores as part of its plan to be the province’s sole distributor of legal recreational marijuana.In currency markets, the Canadian dollar closed an average trading value of US79.35¢, up 0.04 of a U.S. cent — ending last week’s five-day slide.Also readLoonie down amid market turmoil, but not for longOn the commodities front, the March crude contract was up US9¢ to US$59.29 per barrel after sharp drops all of last week and the March natural gas contract was down US3¢ at US$2.55 per mmBTU.The April gold contract was up US$10.70 to US$1,326.40 an ounce and the March copper contract was up US5¢ to US$3.09 a pound. Canada’s main stock index surged more than 200 points in a broad-based advance as U.S. stocks rallied for a second session in a row, erasing some of the massive losses suffered last week.The gains came after the Toronto stock index dropped more than 8% from its all-time high and leading Wall Street indexes slumped into a “correction” for the first time in two years. Market commentators believe the abrupt stock market rout that began two Fridays ago might have been triggered by a combination of events that rattled investors, including worries about a potential rise in U.S. inflation or interest rates. Toronto stock market dips on weakness in the energy and financials sectors Related news S&P/TSX composite hits highest close since March on strength of financials sector Share this article and your comments with peers on social media Keywords Marketwatch Digital design economic Stock market chart bluebay/123RF TSX gets lift from financials, U.S. markets rise to highest since March David Hodges Facebook LinkedIn Twitterlast_img read more

Treasurer confirms secret plan to cut super and force retirees to sell their family home Article

first_imgTreasurer confirms secret plan to cut super and force retirees to sell their family home Article Retirees could be left with no choice but to sell their family home under a secret plan being considered by the federal government.In a speech today the Treasurer Josh Frydenberg backed the Retirement Income Review findings that more retirees should use their savings more “efficiently” – which includes selling the family home.The use of the “efficiency” code word is a nod to the extreme elements of the backbench that the Treasurer might follow through on their scheme to cut super.This underhanded plan to break an election promise and cut super would leave the average 30-year-old couple $170,000 less at retirement. To make up for the shortfall a government review, the Superannuation Minister and now the Treasurer have all indicated retirees should sell down the home. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:efficiency, election, election promise, Family, federal government, Force, Government, Industry Super Australia, Josh Frydenberg, Minister, retirement, Retirement Income Review, super, superannuationlast_img read more

2021-22 Draft Budget prioritises service delivery for community

first_img2021-22 Draft Budget prioritises service delivery for community Mildura Rural City Council’s 2021-22 Draft Budget has been released with a sharp focus on uninterrupted delivery of the more than 100 crucial services Council provides the community, despite the financial pressures of the global pandemic and other emergencies including drought and climate change.Mildura Mayor Jason Modica said like many businesses and organisations around Australia, Council’s operations had been impacted by the pandemic, resulting in a need to prioritise spending.“Council has adapted services and continued to deliver a capital works program to ensure our community is supported during these challenging 12 months,” Cr Modica said.“Over the past year we’ve delivered millions of dollars in COVID-19 support to our community, had increased costs particularly in regard to cleaning and maintenance and seen some revenue sources reduced,” Cr Modica said.“This has meant a forecast $1.01 million deficit for 2021-22, meaning we’ve needed to make some tough decisions to ensure our budget continues to support delivery of services our community expects and needs.”Council’s total proposed budget for the 2021-22 Financial Year is $145.07 million. Reduced spending in some areas, such as a $7 million cut to capital works compared to last year, will ensure vital services continue, including:$7.87 million for youth, children and family services$5.66 million for aged services$3.55 million customer services$3.36 million for community safety, health and wellbeing.This investment allows Council to provide aged and disability support for 1,500 residents, administer 13,500 immunisations, deliver 7,800 Maternal and Child Health appointments, support hundreds of local young people through Youth Services programs and assist around 700 children to enrol in local kindergartens.Despite the current financial pressures, Council has not sought any increase over the Victorian Government’s Fair Go Rate cap for 2021-22, which is 1.5%. This is Council’s lowest rate increase in more than a decade.“In working through this year’s Draft Budget Councillors and staff have tried wherever possible to avoid passing financial pressures on to the community, and I believe we have achieved that,” Cr Modica said.While the $43.73 million capital works program is smaller than last year, Council will continue to upgrade and maintain important infrastructure that locals need to go about their daily lives. This includes investing:$14.20 million on roads projects$2.88 million for waste management projects$1.93 million on recreation and leisure projects$490,000 on parks, playgrounds and treesThe Draft Budget also includes $16.6 million for two major projects that present significant social and economic benefits for our community. Stage 2 of the Mildura South Regional Sporting Precinct will include construction of squash courts, an additional administration hub, second playing oval, car park expansion and landscaping to compliment Stage 1 of the project that is due for completion mid-2021. The Powerhouse precinct on Mildura’s riverfront will also be revitalised with significant improvements.Some other key capital works projects budgeted for in 2021-22 include:Renovations to the Lake Cullulleraine Community Complex and improvements to the Lake Cullulleraine foreshoreRedevelopment and landscaping to Mildura’s Deakin Avenue median between Eighth and Ninth StreetsConstruction of a glass sorting and reprocessing facility at Mildura LandfillLighting upgrade at Henshilwood Recreation Reserve, IrympleNew cricket nets at Quandong Park, Red CliffsThe community is invited to view the 2021-22 Draft Budget in full and provide feedback on its contents. Copies are available online at mildura.vic.gov.au/haveyoursay or can be requested by calling 03 5018 8100. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Australia, children, climate change, community, Cullulleraine, Government, health, infrastructure, Investment, Irymple, local council, Mildura, Mildura Rural City Council, Quandong, Red Cliffs, spending, Victoria, wellbeing, Youthlast_img read more

2018 Subaru Outback is more luxurious – and still one of the best anti-CUVs

first_img But tread wear isn’t the only factor to consider when it comes to tire safety. Cracked rubber can also render a tire unusable. Weather cracking can appear on both the sidewalls and tread faces of tires and is usually related to age and exposure to the elements. There’s a popular myth that once tires reach a certain age, they can no longer be retailed or used on the roads regardless of their condition. Tire manufacturers, retailers and vehicle owners aren’t restricted as such; if a tire is properly stored and not exposed to sunlight or extreme elements, it can have an almost unlimited shelf life.RELATED The difference between all-weather and all-season tiresSurface cracks don’t necessarily condemn a tire to the recycling yard; it depends on their depth. To check, take a flat (and hopefully dull) screwdriver, gently insert into the crack and twist it slightly to see how deep the crack goes. If you can see any sign of the tire’s support cords (usually appearing as light-coloured yarn-sized strings), the tire is toast. ‹ Previous Next › COMMENTSSHARE YOUR THOUGHTS If you’re the type of driver who doesn’t put a lot of kilometres on either your summer or winter tires, taking the time to treat them with some rubber preservative can go a long way to prevent weather cracking. There’s a wide selection of products on the shelves of every auto parts store, or you can simply use silicone lubricating compound (in a spray can), and also use it for general lube and protection purposes on other parts of the vehicle. A quick spray every other month or so is all it takes, but don’t forget to do both sides of each tire. PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca RELATED TAGSSafety and MaintenanceMaintenanceNew VehiclesAutomotive SafetyAutomotive TechnologyCanadaOntarioScience and TechnologyTechnologyVehicle Control Created with Raphaël 2.1.2Created with Raphaël 2.1.2 Tread wear isn’t the only factor to consider when it comes to tire safety. Rubber cracking can also render a tire unusable. Buy It! Princess Diana’s humble little 1981 Ford Escort is up for auction An engagement gift from Prince Charles, the car is being sold by a Princess Di “superfan”center_img See More Videos The Rolls-Royce Boat Tail may be the most expensive new car ever We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. Trending in Canada advertisement Trending Videos It’s seasonal tire change-over time and from coast to coast, repair shops of every type are busy removing winter tires and installing summers (those that tire-makers euphemistically call all-seasons). Many do-it-yourselfers complete this task in their driveways thanks to their foresight that led them to purchase a separate set of rims for their rides’ boots. But what’s the best way to know if your tires are going to be good for another season of safe, worry-free driving?Just about every driver knows about tread wear and how to recognize tires worn beyond their safe limit, but a refresher never hurts. If you examine the face of any tire’s tread, you will notice slightly raised rubber bars or ridges running across the bottom of the treads (from inside to outside edges) every 12 inches or so. These are wear-bar indicators, and if any portion of the treads is worn to the point where the wear bars are at the surface, the tire is not fit for the road. Tread-depth gauges are easy to use and only cost about $5; they are available from just about every auto parts store in the land. Most jurisdictions in Canada require a minimum of approximately 1/16th of an inch of tread depth to meet regulated safety standards, and Ontario recently raised that bar to 2 mm.  last_img read more

NCAA boards, DiStefano endorse reforms to college basketball

first_imgChancellor Philip P. DiStefanoThe commission recommendations will “ensure integrity in the game, strengthen accountability in college sports and demonstrate a commitment to the well-being of student-athletes,” the NCAA statement said.Division I basketball was plagued last season by well-publicized allegations of bribery and corruption that led to federal prosecutors’ charges against some assistant coaches and an apparel company executive.Federal prosecutors allege that an Adidas executive and others with ties to the company bribed players’ families and college coaches to entice top prospects to commit to schools that Adidias sponsored. Those players later signed contracts to endorse the company’s products.The commission, in its recommendations, called for:The end of the “one-and-done” practice in which top players only play their freshman season before moving onto the NBA.The establishment of a new system for summer basketball—essential to the recruitment process—that would keep out apparel companies.Coaching and administrator contracts that require cooperation with NCAA investigations.That coaches, athletic directors and college presidents certify annually that their athletic programs comply with NCAA rules.The establishment an independent investigative body for major issues.DiStefano endorsed the recommendations.Division I council members will forward final changes to the Division I Board and the Board of Governors for approval in August, the NCAA said in the statement.DiStefano said that one key to successful reform is the NCAA working closely with other organizations outside the NCAA – including USA Basketball, apparel companies, the National Basketball Association and its players’ association to make meaningful and lasting changes that will support the commission’s recommendations.“If we don’t have a strong collaboration then we won’t achieve recommendations by the commission,” DiStefano said.Summary of recommendations from the Commission on College BasketballEnd One-and-Done. Separate the collegiate track from professional by ending one-and-done.Greater Draft Flexibility for Student-Athletes. Allow student-athletes to test their pro prospects and maintain their college eligibility if they do not sign a professional contract.NCAA-Certified Agents to Provide Student-Athletes with Assessment of Professional Prospects. Permit students to receive meaningful assessment of their professional prospects earlier, with assistance from NCAA-certified agents. NCAA appoints a VP to, among other things, develop meaningful standards for certification of agents.Provide Resources to Make the Promise of a College Education Real. NCAA to establish fund to pay for the degree completion of student-athletes with athletic scholarships who leave member institutions after progress of at least two years towards a degree.Independent Investigation and Adjudication of Complex Cases. NCAA to establish independent investigative and adjudicative body.Enact and Impose Core Punishments with Significant Deterrent Effect. Core penalties should be increased to allow 1) Five-year postseason ban for Level I violations; 2) loss of all revenue sharing in post-season play for the entire ban; 3) lifetime bans for a show-cause order; 4) allow bans of more than one season for head coach violations; 5) increase penalties to allow full-year visit bans for recruiting visit violations.NCAA to amend rules to require colleges to include in contracts with administrators and coaches’ contractual obligations to cooperate with NCAA investigations and agree to submission to NCAA enforcement proceedings.Require coaches, athletic directors and college presidents to certify annually that their athletic programs comply with NCAA rules. Reform Non-Scholastic Basketball and Make its Finances Transparent. NCAA should enforce rigorous certification criteria for non-scholastic basketball events that coaches attend. Events should be subject to financial disclosure, an audit of all financial relationships and payments, IRS, and other tax filings. Events must also have educational components.Enlist Apparel Companies in Transparency and Accountability Efforts. Boards of public apparel companies should implement financial transparency and accountability with respect to their investments in non-scholastic basketball.In Cooperation with Partners, Establish NCAA Youth Basketball Programs. With a goal of 2019, we recommend that the NCAA work with USA Basketball, the NBA and the NBPA and others to establish and administer new youth basketball programs.Enact Changes in Rules Governing Recruiting and Coaches’ Interaction with Recruits and Student-Athletes. Reduce the influence of third parties and increase the ability of college coaches to interact with recruits and current players. We endorse adoption of a number of rule changes recommended by the National Association of Basketball Coaches.Add Five Independent Public Members to The NCAA’s Board of Governors.Categories:Deadlines & AnnouncementsCampus Community Published: April 25, 2018 Today the NCAA Board of Governors and Division I Board of Directors, unanimously endorsed a series of recommendations from the Commission on College Basketball, chaired by former Secretary of State Condoleezza Rice. CU Boulder Chancellor Philip DiStefano sits on both NCAA boards. Share Share via TwitterShare via FacebookShare via LinkedInShare via E-maillast_img read more

HALL Wines Surprises Crowds with “Ode to Joy” Flash Mob During…

first_imgReddIt AdvertisementHALL was honored to host the 2015 Auction Napa Valley’s Barrel Auction this year in St. Helena this year and arranged a delightful surprise in partnership with Festival Del Sole and the Napa Valley Vintners. HALL was able to share a joyous surprise to over 2500 guests – an ‘Ode to Joy’ Flash Mob featuring 40 musicians and 40 vocalists of Beethoven’s Immortal 9th Symphony led by renowned conductor Ming Luke.Owners Craig and Kathryn Hall have a passion for music and the arts and are actively involved with Festival Del Sole each year. Additionally, the Hall’s have a collection of contemporary art at each property including HALL St. Helena, HALL Rutherford, WALT Sonoma and SENZA Hotel. By incorporating unique artistic elements into each property, such as a 35ft chrome Bunny Foo Foo rabbit at the entrance to HALL St. Helena, they aim to share the overall Napa experience in every possible way culturally.Kathryn Hall is most known around the world as a public figure as she was our former U.S. Ambassador to Austria during the Clinton Administration.Advertisement Twitter Share Email Linkedin TAGSAuction Napa ValleyfeaturedFestival Del SoleHall WinesNapa Valley Vintners Pinterest Home Industry News Releases HALL Wines Surprises Crowds with “Ode to Joy” Flash Mob During #1…Industry News ReleasesVideoWine BusinessHALL Wines Surprises Crowds with “Ode to Joy” Flash Mob During #1 Wine Auction in the World, Auction Napa ValleyBy Press Release – June 16, 2015 15 0 Facebook Previous articleAfternoon Brief: June 16Next articleHow Customers Respond to Music Press Releaselast_img read more

INST scientists formulate nanoparticle to reduce severity of rheumatoid arthritis

first_img Menopause to become the next game-changer in global femtech solutions industry by 2025 Add Comment Comments (0) Phoenix Business Consulting invests in telehealth platform Healpha MaxiVision Eye Hospitals launches “Mucormycosis Early Detection Centre” Indraprastha Apollo Hospitals releases first “Comprehensive Textbook of COVID-19” Related Posts The missing informal workers in India’s vaccine story WHO tri-regional policy dialogue seeks solutions to challenges facing international mobility of health professionals Heartfulness group of organisations launches ‘Healthcare by Heartfulness’ COVID care app Department of Science and Technology Government of IndiaInstitute of Nano Science & Technology (INST)rheumatoid arthritisScience and Engineering Research Board (SERB)zinc Share Element zinc is vital for maintaining normal bone homeostasis, and its levels are reported to get reduced in rheumatoid arthritis patients and arthritis-induced animalsScientists from the Institute of Nano Science & Technology (INST), Mohali, an autonomous institute of the Department of Science and Technology Government of India, have formulated nanoparticles with chitosan and loaded these nanoparticles with zinc gluconate for reducing the severity of rheumatoid arthritis.Element zinc is vital for maintaining normal bone homeostasis, and its levels are reported to get reduced in rheumatoid arthritis patients and arthritis-induced animals. It is also known that oral supplementation of zinc in the form of zinc gluconate have very low bioavailability in humans.   Chitosan, the biocompatible, biodegradable natural polysaccharide that is one of the most abundant biopolymers obtained from the exoskeleton of crustaceans have shown absorption promoting characteristics. The INST team have particularly chosen chitosan as it is biodegradable, biocompatible, non-toxic, and mucoadhesive. A previously published report in the journal Magnesium Research exhibited that after intraperitoneal administration in rats, zinc oxide in standard form resulted in a slight increase in serum zinc level, whereas that in nano form resulted in significantly high serum zinc levels thus increasing the zinc bioavailability. This motivated the INST team to develop the nanoformulation of zinc gluconate.In the recent past, the ionic gelation method has been widely employed for formulating chitosan nanoparticles, which may contain various medicinally active pharmacological agents. The DST-Science and Engineering Research Board (SERB) and DST-Nanomission supported study led by Dr Rehan Khan, published in ACS Biomaterials Science and Engineering journal has analysed the superior efficacy of zinc gluconate-loaded chitosan nanoparticles over the free form of zinc gluconate.The team prepared zinc gluconate loaded chitosan nanoparticles using chitosan and sodium tripolyphosphate in double-distilled water, and zinc gluconate was simultaneously added along with the synthesis of chitosan nanoparticles. Nanoparticles were characterized for various physicochemical properties, and then anti-arthritic potential was investigated against collagen-induced arthritis in Wistar rats. They observed that the treatment of rats with both zinc gluconate and zinc gluconate loaded chitosan nanoparticles reduced the severity of arthritis by reducing joint swelling, erythema, and oedema but zinc gluconate loaded nanoparticles exhibited superior efficacy. The team assessed various parameters like biochemical analysis, histological observations, and immunohistochemical expression of inflammatory markers and suggested that zinc gluconate-loaded chitosan nanoparticles exerted superior therapeutic effects compared to the free form of zinc gluconate. This they attributed due to the inflammatory potential of zinc gluconate-loaded chitosan nanoparticles.“Nanobiotechnology provides several effective solutions for the problems that traditional pharmaceutical formulations are often not able to address as effectively, such as the sustained and targeted release of drugs, bioavailability, and efficacy of drugs and nutraceuticals, etc. The nanoformulation of zinc gluconate-loaded chitosan nanoparticles developed at INST Mohali is a creative example of a superior therapeutics for rheumatoid arthritis,” said Prof Ashutosh Sharma, Secretary, DST. News By Press Information Bureau on July 13, 2020 INST scientists formulate nanoparticle to reduce severity of rheumatoid arthritis Read Articlelast_img read more

A grand(motherly) surprise

first_img Jacksonville lawyer learns of unsuspected activist history Lucy Ames Edwards and her sister, Cora Ames Byrd, preparing to lead the women of Randolph-Macon Woman’s College in Lynchburg, Va., on a 1917 march in Washington, D.C., in support of the 19th Amendment to the U.S. Constitution.Jacksonville attorney Thomas S. Edwards, Jr., knew quite a bit about his grandfather, Ray Edwards, who died before the younger Edwards was born.A wounded WWI veteran and engineer, the senior Edwards moved to Jacksonville with his wife, Lucy Ames Edwards, in the 1930s to run local Civilian Conservation Corps operations. He went on to be founding president of the Duval County Housing Authority (one of the first housing projects in the country), construct seawalls up and down the Florida coast (many of which are still standing), and work on the building of the interstate highway system.“I have correspondence between my granddad and the president of the United States advocating for the funding of the housing projects,” Edwards said. “There was an entire generation of leaders in the city of Jacksonville who were raised in those projects [including former Florida Supreme Court Justice Harry Lee Anstead].”About his grandmother, who never remarried after her husband died and lived to 100, Edwards knew she had been a teacher, was devoted to her church and family, was an avid reader, and loved to travel.“She was a life member of the Audubon Society and she absolutely loved to travel and birdwatch,” he said. “She did photos of all her travels and photos of hikes looking at different kinds of birds, and to a lesser degree other animals and flowers.”The result was slide shows presented at churches, Audubon Society meetings, and her grandchildren’s school classes.What he hadn’t suspected was the activism that marked his grandmother’s early life. It was recently unearthed by a more than 100-year-old picture that his sister, Ginny, found in one of his grandmother’s photo albums.In honor of the 100th anniversary of women winning the right to vote, Edwards posted the picture online during this year’s Law Day celebrations.As Edwards put it in the Facebook post, “To our surprise, our staid, conservative, church going grandmother was a radical in her youth! She was President of the Class of 1917 at Randolph-Macon Woman’s College [now Randolph College, in Lynchburg, Va.]! This picture is of her preparing to lead the women of Randolph-Macon on a march in Washington, D.C., in support of the 19th Amendment to the U.S. Constitution. We believe this was taken in 1917 and she is accompanied by her sister, Cora Ames Byrd — Class of 1919.“What they did was controversial — women marching were spat upon and otherwise attacked — though generally not with the violence of the later civil rights marches. These women were regularly attacked in the press of the day.”Edwards linked a story about the war of postcards — the memes of the time — that surrounded the suffragette battles in both England and the U.S. (https://www.collectorsweekly.com/articles/war-on-women-waged-in-postcards-memes-from-the-suffragist-era/). The article recounted how protesting women in both countries were sometimes arrested and when some then went on hunger strikes, they were force fed.He sees some of his grandmother’s traits in his professional life, noting her time as a teacher.“As a lawyer who does trial work, a part of that is effectively teaching juries,” Edwards said. “She had an intellectual curiosity and was a big reader throughout her life. As a trial lawyer, you’re learning every day.”He mused, “I’m not sure what else I’d do if I wasn’t doing what I’m doing every day. It’s an intellectual challenge every day.”Ah.Perhaps that’s best summed up by the motto of his grandmother’s college: “Vita Abundantior” or Life More Abundant. A grand(motherly) surprise Sep 28, 2020 By Gary Blankenship Senior Editor Top Storieslast_img read more